gms | German Medical Science

23rd Annual Meeting of the German Retina Society

German Retina Society

24.09. - 25.09.2010, Freiburg

Treatment of juuxtapapillary uveal melanomas

Meeting Abstract

  • Michael Freistühler - University Eye Clinic Essen
  • M. Gök - University Eye Clinic Essen
  • D. Flühs - University Eye Clinic Essen
  • W. Sauerwein - University Eye Clinic Essen
  • N. Bornfeld - University Eye Clinic Essen

German Retina Society. 23rd Annual Conference of the German Retina Society. Freiburg i. Br., 24.-25.09.2010. Düsseldorf: German Medical Science GMS Publishing House; 2010. Doc10rg35

doi: 10.3205/10rg35, urn:nbn:de:0183-10rg357

This is the translated version of the article.
The original version can be found at:

Published: September 21, 2010

© 2010 Freistühler et al.
This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( You are free: to Share – to copy, distribute and transmit the work, provided the original author and source are credited.



Objective: Comparison of the clinical course of patients with uveal melanomas near the optic nerve concerning tumour localisation, tumour height and primary tumour destructive therapy.

Methods: Retrospective data assessment of 348 patients with an uveal melanoma near the optic nerve and were primary treated with: a)brachytherapy with 106Ru-plaques, b)106Ru-125I-binuclid plaques, c)proton beam irradiation, d)combined treatment modality consisting of brachytherapy with 106Ru-plaques and transpupillary thermotherapy.

Evaluation of the clinical course (mean follow-up 50 months) considering primary tumour destructive treatment, complications, visual acuity, tumour localisation, tumour height.

Results: Primary brachytherapy with 106Ru-125I-binuclid plaques had the worst and primary brachytherapy with 106Ru-plaques had the best results. The combined treatment of brachytherapy and TTT increase the rate of blindness and decrease the rate of tumour recurrence. Using proton beam irradiation tumour recurrence was statistically higher (if safety margin was reduced) and however the decrease of visual acuity developed more slowly it was not statistically better than in the brachytherapy group..

Conclusions: Planning treatment of juxtapapillary uveal melanomas both tumour height and localisation should be considered. However proton beam irradiation had a small benefit in central tumours, the results in visual acuity were the same after manifestation of radiogenic retinopathy. Large uveal melanomas had a poor prognosis in general, especially with temporal localisation.