gms | German Medical Science

23rd Annual Meeting of the German Retina Society

German Retina Society

24.09. - 25.09.2010, Freiburg

Endoresection of large uveal melanoms after pretreatment by single-dose stereotactic convergence irradiation with gamma-knife and adjuvant brachytherapy – long term results

Meeting Abstract

  • Eva Biewald - University Eye Clinic Essen
  • M. Freistühler - University Eye Clinic Essen
  • M. Gök - University Eye Clinic Essen
  • B. Jurklies - University Eye Clinic Essen
  • W. Sauerwein - University Eye Clinic Essen, Clinic und Policlinic for Radiotherapy
  • G. A. Horstmann - Gamma Knife Centre, Krefeld
  • N. Bornfeld - University Eye Clinic Essen

German Retina Society. 23rd Annual Conference of the German Retina Society. Freiburg i. Br., 24.-25.09.2010. Düsseldorf: German Medical Science GMS Publishing House; 2010. Doc10rg32

doi: 10.3205/10rg32, urn:nbn:de:0183-10rg329

This is the translated version of the article.
The original version can be found at:

Published: September 21, 2010

© 2010 Biewald et al.
This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( You are free: to Share – to copy, distribute and transmit the work, provided the original author and source are credited.



Background: The therapy of large uveal melanomas remains a challeging task in ophthalmology. The aim of this retrospective study was to compare the results of the brachytherapy with ruthenium-iodone and the surgical removal after gamma-knife and adjuvant brachytherapie.

Methods: We compared the longterm results of large uveal melanomas after gamma-knife, endoresection and adjuvant brachytherapy to a treatment with iodine-ruthenium alone. Specical focus was laid on visual acuity, tumor control and the rate of secondray enucleation.

Results: The frequency of secondary enucleation was significantly lower in the endoresection group. At the same time viusal acuity could be obtained at a higher level in the surgery group.

Conclusion: Eyes with large uvela melanomas can be salvaged by stereotactic radiotherapy followed by endoresection and adjuvant brachtherapy.