gms | German Medical Science

23rd Annual Meeting of the German Retina Society

German Retina Society

24.09. - 25.09.2010, Freiburg

Retrospective analysis to evaluate risk factors for radiation retinopathy in patients received proton beam radiation as a treatment for choroidal melanoma

Meeting Abstract

  • Vinodh Kakkassery - Charité, University School of Medicine Berlin, University Eye Clinic, Campus Virchow Clinic and Campus Benjamin Franklin, Berlin
  • G. Willerding - Charité, University School of Medicine Berlin, University Eye Clinic, Campus Virchow Clinic and Campus Benjamin Franklin, Berlin
  • D. Cordini - Charité, University School of Medicine Berlin, BerlinProtonen centre for eye tumors at the Helmholtz centre, Berlin
  • S. Winterhalter - Charité, University School of Medicine Berlin, University Eye Clinic, Campus Virchow Clinic and Campus Benjamin Franklin, Berlin
  • J. Heufelder - Charité, University School of Medicine Berlin, BerlinProtonen centre for eye tumors at the Helmholtz centre, Berlin
  • A.M. Joussen - Charité, University School of Medicine Berlin, University Eye Clinic, Campus Virchow Clinic and Campus Benjamin Franklin, Berlin

German Retina Society. 23rd Annual Conference of the German Retina Society. Freiburg i. Br., 24.-25.09.2010. Düsseldorf: German Medical Science GMS Publishing House; 2010. Doc10rg29

DOI: 10.3205/10rg29, URN: urn:nbn:de:0183-10rg297

This is the translated version of the article.
The original version can be found at: http://www.egms.de/de/meetings/rg2010/10rg29.shtml

Published: September 21, 2010

© 2010 Kakkassery et al.
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by-nc-nd/3.0/deed.en). You are free: to Share – to copy, distribute and transmit the work, provided the original author and source are credited.


Outline

Text

Introduction: Radiation retinopathy, a complication of choroidal melanoma radiation, compromise the visual acuity two to three years after therapy and may lead in severe cases to rubeosis and neovascular glaucoma. Aim of this retrospective study, is to evaluate risk factors for developing radiation retinopathy.

Methods: Data for this retrospective study were obtained from the register of the BerlinProtonen, centre for eye tumors (http://www.berlinprotonen.de/) at Charité in Berlin. Analysis of data were done by Gaussian and Non-Gaussian statistical tests. Patients were classified in no radiation retinopathy or radiation retinopathy. Category radiation retinopathy included patients with a radiation retinopathy stadium I to IV according to the classification of Paul T Finger (New York/ USA). Results were rechecked for statistical significance in cooperation with the department for medical statistics at Charité in Berlin.

Results: Data of 584 patients have been registered from 1998 to 2005. 563 patients developed at least a mild form of radiation retinopathy. Statistical analysis demonstrate a significant higher age, total dose of radiation and fovea dose of radiation. No significant differences were seen for gender, papillary dose and ciliary body dose.

Conclusion: Results for proton beam radiation are conforming findings in ophthalmic plaque therapy. Patients with risk factors for radiation retinopathy like age, total dose und fovea dose should visit an ophthalmologist on a regular basis. Standard therapies have to be established and differences between laser therapy and intravitreal therapy have to be evaluated.