gms | German Medical Science

23rd Annual Meeting of the German Retina Society

German Retina Society

24.09. - 25.09.2010, Freiburg

Small dense particles within the neurosensory retinal layers observable by Spectral Domain Optical Coherence Tomography in Age-related macular Degeneration

Meeting Abstract

  • Carsten Framme - University Eye Clinic Inselspital Bern
  • S. Wolf - University Eye Clinic Inselspital Bern
  • U. Wolf-Schnurrbusch - University Eye Clinic Inselspital Bern

German Retina Society. 23rd Annual Conference of the German Retina Society. Freiburg i. Br., 24.-25.09.2010. Düsseldorf: German Medical Science GMS Publishing House; 2010. Doc10rg03

doi: 10.3205/10rg03, urn:nbn:de:0183-10rg037

This is the translated version of the article.
The original version can be found at:

Published: September 21, 2010

© 2010 Framme et al.
This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( You are free: to Share – to copy, distribute and transmit the work, provided the original author and source are credited.



Purpose: To observe detailed changes of neurosensory retinal structure after Anti-VEGF upload in age-related macular degeneration (AMD) using spectral domain optical coherence tomography (SD-OCT).

Material and methods: The retinal structure was observed in 61 patients using the Spectralis-OCT (Heidelberg engineering, Germany) before and one months after third Ranibizumab injection (upload phase). The main focus of attention was subjectively laid on the amount and behaviour of the numerous small dense particles (SDP) frequently observable within the outer and inner neurosensory layers in eyes suffering from neovascular AMD. For statistical analysis the Spearmans Rho correlations were used (SPSS for Windows 16.0).

Results: In all eyes SDPs of various amounts were seen within the neurosensory layer of the foveal and parafoveal area. In 54% the amount of SDP became significantly less after therapy (stable 41%, more 5%). The SDP reduction was positively correlated with the reduction of retinal pathology in the OCT (p=0.000), with central foveal thickness (p=0.040) and with the increase of best corrected visual acuity (BCVA; p=0.006). The baseline amount of SDPs was also positively correlated with the increase of BCVA (p=0.005).

Conclusion: The origin of SDP observable in SD-OCT is unknown but might represent migrating RPE cells or leucocytes indicating a certain status of retinal inflammation. SDP amount is predominantly reduced after Ranibizumab upload therapy and positively correlated to BCVA. Moreover, an initial larger number of SDPs might indicate a higher grade of inflammation but better results of Ranibizumab therapy were achieved. Thus, the amount of SDPs before treatment might be a predictive factor for therapy outcome.