gms | German Medical Science

23rd Annual Meeting of the German Retina Society

German Retina Society

24.09. - 25.09.2010, Freiburg

Is the visualisation of outer retinal layers in OCT analysis a good predictive factor for visual outcome in exudative AMD?

Meeting Abstract

  • Maria-Andreea Gamulescu - University Eye Clinic Regensburg
  • G. Panagakis - University Eye Clinic Regensburg
  • C. Theek - University Eye Clinic Regensburg
  • H. Helbig - University Eye Clinic Regensburg

German Retina Society. 23rd Annual Conference of the German Retina Society. Freiburg i. Br., 24.-25.09.2010. Düsseldorf: German Medical Science GMS Publishing House; 2010. Doc10rg02

doi: 10.3205/10rg02, urn:nbn:de:0183-10rg024

This is the translated version of the article.
The original version can be found at:

Published: September 21, 2010

© 2010 Gamulescu et al.
This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( You are free: to Share – to copy, distribute and transmit the work, provided the original author and source are credited.



Background: Good visualisation of outer retinal layers in OCT analysis, especially external limiting membrane (ELM) and the border of inner/outer photoreceptor layer (IS/OS), seems to be associated with good visual function. Here we investigated, if good pre-operative visualisation of those layers can be used as a predictive factor for visual outcome.

Methods: Retrospective review of 87 previously untreated patients with exudative AMD who received 3 monthly intravitreal ranibizumab injections. Visual acuity before beginning of intravitreal therapy and 4–6 weeks after last intravitreal injection was compared and related to the pre-operative visualisation and continuity of the outer retinal layers in spectral-domain OCT.

Results: Visual acuity increased in 40 of 87 (46.0%) patients at least 1 line, 25 (28.7%) remained stable and 22 (25.3%) had decreased visual acuity of at least 1 line 4–6 weeks after third intravitreal ranibizumab injection. No statistical significant predictive value was demonstrated in any of the calculations for ELM or IS/OS concerning post-operative visual acuity.

Conclusion: In our series of AMD patients, grade of visibility and continuity of outer retinal layers was not a good predictive value for post-operative visual acuity development.