Article
Is the visualisation of outer retinal layers in OCT analysis a good predictive factor for visual outcome in exudative AMD?
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Published: | September 21, 2010 |
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Background: Good visualisation of outer retinal layers in OCT analysis, especially external limiting membrane (ELM) and the border of inner/outer photoreceptor layer (IS/OS), seems to be associated with good visual function. Here we investigated, if good pre-operative visualisation of those layers can be used as a predictive factor for visual outcome.
Methods: Retrospective review of 87 previously untreated patients with exudative AMD who received 3 monthly intravitreal ranibizumab injections. Visual acuity before beginning of intravitreal therapy and 4–6 weeks after last intravitreal injection was compared and related to the pre-operative visualisation and continuity of the outer retinal layers in spectral-domain OCT.
Results: Visual acuity increased in 40 of 87 (46.0%) patients at least 1 line, 25 (28.7%) remained stable and 22 (25.3%) had decreased visual acuity of at least 1 line 4–6 weeks after third intravitreal ranibizumab injection. No statistical significant predictive value was demonstrated in any of the calculations for ELM or IS/OS concerning post-operative visual acuity.
Conclusion: In our series of AMD patients, grade of visibility and continuity of outer retinal layers was not a good predictive value for post-operative visual acuity development.