gms | German Medical Science

22nd Annual Meeting of the German Retina Society

German Retina Society

26.06. - 27.06.2009, Berlin

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Effect of intravitreal bevacizumab on retinal pigment epithelium detachment due to occult choroidal neovascularisation

Meeting Abstract

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  • Thomas Ach - University Eye Clinic of Heidelberg
  • M. Ruppenstein - University Eye Clinic of Heidelberg
  • A. E. Höh - University Eye Clinic of Heidelberg
  • R. Amberger - Kirchhoff Institute for Physics, Heidelberg
  • S. Dithmar - University Eye Clinic of Heidelberg

German Retina Society. 22nd Annual Meeting of the German Retina Society. Berlin, 26.-27.06.2009. Düsseldorf: German Medical Science GMS Publishing House; 2009. DocRG2009-19

doi: 10.3205/09rg20, urn:nbn:de:0183-09rg205

This is the English version of the article.
The German version can be found at: http://www.egms.de/de/meetings/rg2009/09rg20.shtml

Published: June 29, 2009

© 2009 Ach et al.
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by-nc-nd/3.0/deed.en). You are free: to Share – to copy, distribute and transmit the work, provided the original author and source are credited.

Outline

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Purpose: To determine the effect of intravitreal bevacizumab on pigment epithelium detachment (PED) due to occult choroidal neovascularisation (CNV) in age-related macular degeneration (AMD).

Methods: 71 eyes with PED and additional intra- and/or subretinal fluid (IRF) due to occult CNV received 1.25 mg bevacizumab intravitreally. Baseline and follow-up visits included visual acuity (VA), ophthalmologic and Stratus-OCT examination. Re-injections were performed if IRF persisted, PED increased or VA decreased (>1 line on EDTRS charts). Changes in PED height were measured with computer assisted software.

Results: 71 eyes of 67 patients (75.8±6.4 years) received 3±1.8 injections during 39.4±26.6 weeks follow-up. At last visit, VA was stabilized (0.53±0.28 vs. 0.54±0.45 logMAR; p=0.864) while PED height decreased slightly (303±183 vs. 260±185 µm; p=0.055). In 54% PED height decreased (group 1), while in 46% PED height remained stable or increased (group 2). At baseline, group 1 had a significant worse VA (0.60±0.26 vs. 0.44±0.26 logMAR; p=0.008) and a significant larger PED height (356±180 vs. 241±170 µm; p=0.003). In four eyes (5.6%) PED flattened completely.

Conclusions: Half of the patients benefit of PED flattening during treatment period. In particular distinct PED respond to intravitreal bevacizumab. Intravitreal bevacizumab might stabilize visual acuity in occult CNV and PED, but PED flattening does not correlate with increase of VA automatically.