Article
Inhibitors of the carbonic anhydrase as „novel“ therapy of diabetic macular edema
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Published: | June 29, 2009 |
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Therapy of macular edema of various origin by acetazolamide is an established approach although the cellular mechanis of its action is unclear. There was a recent publication in Natur Medicine in 2008, giving a new rational to this classical therapy of macular edema [Ref. 1]. The authors could demonstrate conclusively that pH effects mediated by carbonic anhydrase contribute to vascular leackage in diabetes. An inhibition of the carbonic anhydrase reduces leakage and tightens the vascular walls. These experimental study has not only implications for therapy with carbonic anhydrase inhibitors, but gives also explanations for the success of an early vitrectomy of diabetic patients. This presentation intends to discuss these aspects and introduce the results of an own experimental study with inhibition of carbonic anhydrase in a CNV model.
References
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