gms | German Medical Science

22nd Annual Meeting of the German Retina Society

German Retina Society

26.06. - 27.06.2009, Berlin

Inhibitors of the carbonic anhydrase as „novel“ therapy of diabetic macular edema

Meeting Abstract

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  • Oliver Zeitz - University Eye Clinic of Hamburg

German Retina Society. 22nd Annual Meeting of the German Retina Society. Berlin, 26.-27.06.2009. Düsseldorf: German Medical Science GMS Publishing House; 2009. DocRG2009-13

doi: 10.3205/09rg13, urn:nbn:de:0183-09rg132

This is the English version of the article.
The German version can be found at: http://www.egms.de/de/meetings/rg2009/09rg13.shtml

Published: June 29, 2009

© 2009 Zeitz.
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by-nc-nd/3.0/deed.en). You are free: to Share – to copy, distribute and transmit the work, provided the original author and source are credited.


Outline

Text

Therapy of macular edema of various origin by acetazolamide is an established approach although the cellular mechanis of its action is unclear. There was a recent publication in Natur Medicine in 2008, giving a new rational to this classical therapy of macular edema [1]. The authors could demonstrate conclusively that pH effects mediated by carbonic anhydrase contribute to vascular leackage in diabetes. An inhibition of the carbonic anhydrase reduces leakage and tightens the vascular walls. These experimental study has not only implications for therapy with carbonic anhydrase inhibitors, but gives also explanations for the success of an early vitrectomy of diabetic patients. This presentation intends to discuss these aspects and introduce the results of an own experimental study with inhibition of carbonic anhydrase in a CNV model.


References

1.
Gao BB, Clermont A, Rook S, Fonda SJ, Srinivasan VJ, Wojtkowski M, Fujimoto JG, Avery RL, Arrigg PG, Bursell SE, Aiello LP, Feener EP. Extracellular carbonic anhydrase mediates hemorrhagic retinal and cerebral vascular permeability through prekallikrein activation. Nat Med. 2007;13(2):181-8. DOI: 10.1038/nm1534 External link