gms | German Medical Science

21st Annual Meeting of the German Retina Society and 8th Symposium of the International Society of Ocular Trauma (ISOT)

German Retina Society
International Society of Ocular Trauma

19.06. - 22.06.2008, Würzburg

Anti-VEGF treatment of post-traumatic choroidal neovascularisation (CNV)

Meeting Abstract

  • Ernest Boiko - St. Petersburg/Russia
  • S. Sosnovsky - St. Petersburg/Russia
  • I. Smirnov - St. Petersburg/Russia
  • O. Filohina - St. Petersburg/Russia
  • E. Buzina - St. Petersburg/Russia
  • I. Getmanova - St. Petersburg/Russia

Retinologische Gesellschaft. International Society of Ocular Trauma. 21. Jahrestagung der Retinologischen Gesellschaft gemeinsam mit dem 8. Symposium der International Society of Ocular Trauma. Würzburg, 19.-22.06.2008. Düsseldorf: German Medical Science GMS Publishing House; 2008. DocISOTRG2008P03

The electronic version of this article is the complete one and can be found online at:

Published: June 18, 2008

© 2008 Boiko et al.
This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( You are free: to Share – to copy, distribute and transmit the work, provided the original author and source are credited.



Background: The closed globe eye trauma sometimes is accompanied by choroidal rupture in macula area. This creates condition for development of ischemia. Consequently, it results in development of choroidal neovascularisation, which leads to significant loss of central vision.

Methods: Under the observation there were 11 patients (12 eyes) aged from 18 to 36, with posttrau-matic CNV. Previously all patients suffered from closed globe eye trauma and choroidal rupture in macula location.Ophthalmic examination included visometry, computer perimetry, biomicroophthalmoscopy, tonometry, OCT, FAG. Patients were examined before and month after intravitreal bevacizumab injection (IVBI). Bevacizumab (1.25 mg) was injected through pars plana in the aseptic conditions of op-room. After IVBI all patients received topical antibiotics and steroids.

Results: The mean baseline preop visual acuity was 20/200 and month after IVBI it increased to 20/80. Stable improving of visual acuity during 6 months observed for 7 (63,6%) patients. The baseline brightness response level of central visual field (CVF) was 61,4±22,1 dB and month after IVBI it was 71,8±14,2 dB (p<0.05). The preop central macular thickness was 576±70,4 μm and month after IVBI it was 298±81,2 µm (p<0.01).

Conclusion: IVBI is the effective method of treatment of posttraumatic CNV. Treated eyes responsed by a significant decrease in macular thickness, improvement in visual acuity and increase of brightness level of CVF.