gms | German Medical Science

21st Annual Meeting of the German Retina Society and 8th Symposium of the International Society of Ocular Trauma (ISOT)

German Retina Society
International Society of Ocular Trauma

19.06. - 22.06.2008, Würzburg

Vital dyes for intraocular surgery

Meeting Abstract

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  • Christos Haritoglou - München/Germany

Retinologische Gesellschaft. International Society of Ocular Trauma. 21. Jahrestagung der Retinologischen Gesellschaft gemeinsam mit dem 8. Symposium der International Society of Ocular Trauma. Würzburg, 19.-22.06.2008. Düsseldorf: German Medical Science GMS Publishing House; 2008. DocISOTRG2008V132

The electronic version of this article is the complete one and can be found online at:

Published: June 18, 2008

© 2008 Haritoglou.
This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( You are free: to Share – to copy, distribute and transmit the work, provided the original author and source are credited.



The application of vital dyes during vitreoretinal surgery greatly facilitates the visualization of different structures including the inner limiting membrane (ILM), epiretinal membranes or the vitreous. Indocyanine green was the first dye introduced for the staining of the ILM. Recent data indicate a potential toxic effect of ICG, with the underlying pathomechanisms not being understood completely. A novel dye for ILM staining is Brilliant blue G, which seems to have a much better safety profile compared to ICG. Another blue dye is Trypan blue to visualize epiretinal membranes. Trypan blue can either be injected into the airfilled globe or, after having been diluted with glucose into the fluid-filled globe. The presentation will focus on new safety studies on Brilliant blue obtained in animal studies and will discuss clinical data obtained in humans as well as ultrastructural features of tissue removed during surgery. In addition, other dyes, which are currently under investigation, such as Bromphenol blue, will be discussed and a perspective for future concepts will be given.