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21st Annual Meeting of the German Retina Society and 8th Symposium of the International Society of Ocular Trauma (ISOT)

German Retina Society
International Society of Ocular Trauma

19.06. - 22.06.2008, Würzburg

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Macular Pucker surgically excised from eyes with traumatic disease. Immunohistochemestry study

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  • David E. Pelayes - Buenos Aires/Argentina
  • L. Racca - Buenos Aires/Argentina
  • J.O. Zarate - Buenos Aires/Argentina

Retinologische Gesellschaft. International Society of Ocular Trauma. 21. Jahrestagung der Retinologischen Gesellschaft gemeinsam mit dem 8. Symposium der International Society of Ocular Trauma. Würzburg, 19.-22.06.2008. Düsseldorf: German Medical Science GMS Publishing House; 2008. DocISOTRG2008V064

The electronic version of this article is the complete one and can be found online at: http://www.egms.de/en/meetings/rg2008/08rg066.shtml

Published: June 18, 2008

© 2008 Pelayes et al.
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by-nc-nd/3.0/deed.en). You are free: to Share – to copy, distribute and transmit the work, provided the original author and source are credited.

Outline

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Purpose: To histopathologically evaluate the macular pucker (MP) in traumatized eyes as compared to idiopathic MP.

Methods: The ultrastructurally and immunohistochemically studied MP specimens that were intentionally peeled from ten eyes with traumatic MP (T group), and ten with idiopathic MP (I group). They compared ultrastructural and immunohistochemical findings between the two groups. Include ILM.-H-E, Masson Tricromic, P.A.S. and GFPA , vimentine, Prot. S-100, enolasa neuron specific , factor VIII and CD68 by IHQ.

Results: A larger amount of cellular elements was observed on the vitreous side of the traumatic MP in the T group. The thickness of the MP in the traumatic group was significantly increased (mean 7.9 +/- 1.6 micro) compared with that in the I group (1.8 +/- 0.6 micro) (P < 0.0001). Immunoreactions for Muscle-specific Actin, Factor VIII, CD 68, GFPA and Vimentin in the T group were more abundant in the I group.

Conclusion: The traumatic macular pucker thickening and cell abundance on the vitreous surface might contribute to the course and the pathogenesis of the disease.