gms | German Medical Science

21st Annual Meeting of the German Retina Society and 8th Symposium of the International Society of Ocular Trauma (ISOT)

German Retina Society
International Society of Ocular Trauma

19.06. - 22.06.2008, Würzburg

Anti-VEGF therapy for CNV after closed trauma

Meeting Abstract

  • Ekaterina Chentsova - Moscow/Russia
  • N. Leparskaya - Moscow/Russia
  • V. Tankovskiy - Moscow/Russia
  • R. Gundorova - Moscow/Russia

Retinologische Gesellschaft. International Society of Ocular Trauma. 21. Jahrestagung der Retinologischen Gesellschaft gemeinsam mit dem 8. Symposium der International Society of Ocular Trauma. Würzburg, 19.-22.06.2008. Düsseldorf: German Medical Science GMS Publishing House; 2008. DocISOTRG2008V061

The electronic version of this article is the complete one and can be found online at:

Published: June 18, 2008

© 2008 Chentsova et al.
This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( You are free: to Share – to copy, distribute and transmit the work, provided the original author and source are credited.



The purpose of the study is to assess the safety and efficacy of Avastin in the treatment of CNV after eye contusion.

Methods: Clinical study of 3 eyes (3 patients) with CNV after eye contusion. CNV formation happened in a month after trauma. Contusion trauma took place 3-6 months ago. All patients were men at the age of 30-40 years. Visual acuity was between 20/200 and 20/100. Intravitreous Avastin 0.2 mg was administered every 6 weeks (2 injections). Mean follow-up after last injection 6 months. OCT scans were made before and after intravitreal injection of Avastin. Fundus examination and OCT discovered the postcontusion central break of uvea.

Results: Visual acuity impoved after fist injection in all cases 20/40. After second injection there were improvement in 2 patients 20/32-and 1 patient 20/25. Macular edema decreased in all cases from 564 µm to about 230 µm, subretinal blood resolved and CNV was scarring in all cases.

Conclusions: Avastin is well tolerated and efficacious in the treatment of CNV in case of central break of uvea after contusion.