gms | German Medical Science

21st Annual Meeting of the German Retina Society and 8th Symposium of the International Society of Ocular Trauma (ISOT)

German Retina Society
International Society of Ocular Trauma

19.06. - 22.06.2008, Würzburg

Traumatic Endophthalmitis Prevention Trial (TEPT)

Meeting Abstract

  • Arne Viestenz - Magdeburg/Germany
  • W.F. Schrader - Würzburg/Germany
  • W. Behrens-Baumann - Magdeburg/Germany

Retinologische Gesellschaft. International Society of Ocular Trauma. 21. Jahrestagung der Retinologischen Gesellschaft gemeinsam mit dem 8. Symposium der International Society of Ocular Trauma. Würzburg, 19.-22.06.2008. Düsseldorf: German Medical Science GMS Publishing House; 2008. DocISOTRG2008V047

The electronic version of this article is the complete one and can be found online at:

Published: June 18, 2008

© 2008 Viestenz et al.
This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( You are free: to Share – to copy, distribute and transmit the work, provided the original author and source are credited.



Background: Posttraumatic endophthalmitis is one of the most severe complications occurring in 3-15% after open globe injuries. Early intravenous antibiotics for 48h have been associated with a low risk of posttraumatic endophthalmitis [0.78%; [1]]. The design of a new study to evaluate the role of an additional intravitreal antibiotic injection in the prevention of posttraumatic endophthalmitis will be presented.

Patients and methods: A prospective, multicenter, randomized controlled study was designed. Patients with penetrating or perforating eye injuries will be recruited over a period of 2 years (until 2010). The wound closure and IOFB (intraocular foreign body) removal must be performed within 24 hours after the trauma. After being grouped into low risk (e.g. metallic IOFB) or high risk patients (e.g. agricultural trauma, organic IOFB) each patient will be randomized for 1) intravenous moxifloxacin only or 2) intravenous moxifloxacin plus intravitreal 1 mg Vancomycin plus 1.25 mg Ceftazidim.

Results: 17 European Departments of Ophthalmology agreed to participate. The rate of posttraumatic endophthalmitis in each group will be statistically compared. The follow up period of this study will last 6 months.

Conclusion: If other Departments of Ophthalmology like to join the study, contact: PD. Dr. med. Arne Viestenz, mail: arne.viestenz@med.ovgu.


Ahuero AE et al. (2007) Low rates of endophthalmitis in a large series of open globe injuries. ARVO e-abstract # 709.