Article
Traumatic Endophthalmitis Prevention Trial (TEPT)
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Published: | June 18, 2008 |
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Outline
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Background: Posttraumatic endophthalmitis is one of the most severe complications occurring in 3-15% after open globe injuries. Early intravenous antibiotics for 48h have been associated with a low risk of posttraumatic endophthalmitis [0.78%; [1]]. The design of a new study to evaluate the role of an additional intravitreal antibiotic injection in the prevention of posttraumatic endophthalmitis will be presented.
Patients and methods: A prospective, multicenter, randomized controlled study was designed. Patients with penetrating or perforating eye injuries will be recruited over a period of 2 years (until 2010). The wound closure and IOFB (intraocular foreign body) removal must be performed within 24 hours after the trauma. After being grouped into low risk (e.g. metallic IOFB) or high risk patients (e.g. agricultural trauma, organic IOFB) each patient will be randomized for 1) intravenous moxifloxacin only or 2) intravenous moxifloxacin plus intravitreal 1 mg Vancomycin plus 1.25 mg Ceftazidim.
Results: 17 European Departments of Ophthalmology agreed to participate. The rate of posttraumatic endophthalmitis in each group will be statistically compared. The follow up period of this study will last 6 months.
Conclusion: If other Departments of Ophthalmology like to join the study, contact: PD. Dr. med. Arne Viestenz, mail: arne.viestenz@med.ovgu.
References
- 1.
- Ahuero AE et al. (2007) Low rates of endophthalmitis in a large series of open globe injuries. ARVO e-abstract # 709.