gms | German Medical Science

48th Meeting of the Particle Therapy Co-Operative Group

Particle Therapy Co-Operative Group (PTCOG)

28.09. - 03.10.2009, Heidelberg

Late effects of particle radiations

Meeting Abstract

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  • E. Blakely - Life Science Division, Lawrence Berkeley National Laboratory , Berkeley, USA
  • M. Roach III - UCSF Helen-Diller Family Comprehensive Cancer Center, San Francisco, USA

PTCOG 48. Meeting of the Particle Therapy Co-Operative Group. Heidelberg, 28.09.-03.10.2009. Düsseldorf: German Medical Science GMS Publishing House; 2009. Doc09ptcog021

doi: 10.3205/09ptcog021, urn:nbn:de:0183-09ptcog0210

Published: September 24, 2009

© 2009 Blakely et al.
This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( You are free: to Share – to copy, distribute and transmit the work, provided the original author and source are credited.



The increasing number of patients surviving proton and carbon radiotherapy warrants a comprehensive investigation of late sequelae from particle radiotherapies. Documentation of these effects will aid evaluation of current radiotherapy protocols as well as elucidate potential countermeasures to minimize adverse effects. Since clinical follow up studies are currently limited, it is important to assess what is known about particle effects in laboratory models used to estimate the risk of late radiation effects in space travel. This presentation will briefly review the pertinent clinical and radiobiological literature relevant to this topic, as well as the status of a new clinical initiative to investigate late effects on charged particle radiotherapy patients treated in Berkeley in the 1970’s to 1990’s.

This work was supported by NASA Grant #NNJ07HC791 and the Department of Radiation Oncology, University of California, San Francisco.