gms | German Medical Science

54. Jahrestagung der Norddeutschen Orthopädenvereinigung e. V.

Norddeutsche Orthopädenvereinigung

16.06. bis 18.06.2005, Hamburg

Therapy of joint cartilage defects in the knee joint using matrix-coupled autologous chondrocyte-transplantation: medium-term results of a 2-year follow-up

Meeting Abstract

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  • corresponding author O. Meyer - St. Anna-Hospital, Universität Witten Herdecke, Klinik für Orthopädie, Herne
  • G. Godolias - Herne

Norddeutsche Orthopädenvereinigung. 54. Jahrestagung der Norddeutschen Orthopädenvereinigung e.V.. Hamburg, 16.-18.06.2005. Düsseldorf, Köln: German Medical Science; 2005. Doc05novK5.08

The electronic version of this article is the complete one and can be found online at:

Published: June 13, 2005

© 2005 Meyer et al.
This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( You are free: to Share – to copy, distribute and transmit the work, provided the original author and source are credited.




Autologous Chondrocyte Transplantation (ACT) has become increasingly widespread in the therapy of discrete cartilage defects. The objective of this prospective study was to examine the medium-term results of a Matrix-coupled Chondrocyte Transplantation (MACT) as a modification of the standard method for the treatment of knee joint cartilage defects and to determine possible advantages or disadvantages of this method.


Between April 2001 and December 2003, 54 patients with discrete cartilage defects were treated by MACT in the knee joint. MRT was performed preoperative in all patients and could be repeated in all patients after 6 and 12 months. The knee joint function, activity level and quality of life of the patient were evaluated pre- and postoperative using the modified Cincinnati Score, the ICRS, the Tegner-Activities-Index and the Lysholm Scores.


49 of the 54 patients were satisfied or more than satisfied with the operation results. All subjective, semi-objective or objective parameters included in the scores showed improvement. Magnetic resonance tomography after 12 and 24 months showed healed cartilage surfaces.


In the follow-up thus far, the results have corresponded to the values reported in the literature for the standard method ACT. However, in MACT there is no periosteum excision or attachment, so that a somewhat smaller access can be selected.