gms | German Medical Science

33rd International Congress on Electrocardiology

International Society of Electrocardiology

Prognostic significance of heart rate turbulence following ventricular premature beats in young patients

Meeting Abstract

  • corresponding author presenting/speaker V. Komoliatova - Moscow Institute Pediatry and Children Surgery, Moscow, Russland
  • L. Makarov - Moscow Institute Pediatry and Children Surgery, Moscow, Russland
  • O. Gorlitskaya - 2 nd Saratov Hospital, Saratov, Russland
  • E. Petukhova - National Medical Surgery Center, Moscow, Saratov, Russland

33rd International Congress on Electrocardiology. Cologne, 28.06.-01.07.2006. Düsseldorf, Köln: German Medical Science; 2007. Doc06ice131

The electronic version of this article is the complete one and can be found online at:

Published: February 8, 2007

© 2007 Komoliatova et al.
This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( You are free: to Share – to copy, distribute and transmit the work, provided the original author and source are credited.



Introduction: Heart rate turbulence (HRT) has recently described as a strong, independent risk stratifier in postinfarct patients. The objective of this study was to investigate significance of HRT in young patients with ventricular premature beats (VPB).

Methods: HRT analyses (turbulence onset – TO and turbulence slope - TS) were performed in 64 patients (22 of them (34,3%) had syncope), 30 male and 34 female (mean age 7 ± 8,2 years) who had VPB occurring during Holter monitoring (HM). There were 44 patients without evidence heart disease (2 had syncope), 3 had long QT syndrome (all had syncope), 9 - catecholaminergic ventricular tachycardia – CVT (all had syncope), 1- arrhythmogenic right ventricular dysplasia (syncope), 1 - Brugada syndromes (no syncope), 1 – short QT syndrome (syncope), 5 – dilated cardiomyopathy – DCM (all had syncope), 1- idiopathic ventricular fibrillation (syncope). 1687 VPB were analyzed. We have calculated TO in all patients (100%) and turbulence slope (TS) in 21 (32,8%). Measures of HRT analysis were used as previously described by Shmidt et al. (1999). During the follow-up period of 1±19 years 28 (40%) patients had adverse passing disease: syncope, heart failure, tolerance towards antiarrhythmic treatment, 8 had sudden cardiac death (1 children with DCM suddenly died during HM).

Results: abnormal results TO (TO>0) were found in all patients with CVT (4,1±11,7), all patients with DCM (0,50±1,2) and 4 patients without evidence heart disease (2 among were having syncope and tolerance towards antiarrhythmic treatment). The sensitivity and specificity for prediction of syncope and sudden death were 27% and 97%. TS in patients with DCM reliable differed from TS in other group (4,15±1,33). TS < 2,5 ms/RR interval has defined only in the patient with DCM, who died during HM, 6 month before TS was 4,4±2,6 ms/RR.

Conclusion: Abnormal measures TO are revealed in children with heart disease. In young patients normal limit TS should be hair then adults -6 ms/RR.