Article
Polymorphism screening
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Published: | February 13, 2006 |
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Outline
Abstract
Pharmacogenetics focuses on the variation between individuals in their response to medicines. The expectations are that with applying pharmacogenetics, individualized treatment regimes will be safer and more efficacious, adverse reactions and effects of new medicines become predictable.
Pharmacogenetic knowledge is progressing fast, polymorphism tests are already carried out in individuals in either private institutions or in academic hospitals. The public demand started to grow for polymorphism test stimulated by commercially advertised tests: Before diffusing into the health care system - unevaluated and eventually with unintended effects - this early assessment on the socio-economic impact of individualized medicine aims at informing policy making by advising on regulatory issues and on priority setting.
Three fields of diseases are assessed at ITA:
- polymorphism testing of healthy for genetic predisposition and accordingly early treatment,
- polymorphism testing of patients for their metabolization status and accordingly individualized drug and doses choices and
- genetic testing of tumour tissue and accordingly targeted treatment of selected patients
Notes
The complete lecture can be found on the website of DIMDI: http://www.dimdi.de/static/de/hta/symposien/2005/index.htm