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29. Wissenschaftlicher Kongress der Deutschen Hochdruckliga

Deutsche Hochdruckliga e. V. DHL ® - Deutsche Hypertonie Gesellschaft Deutsches Kompetenzzentrum Bluthochdruck

23. bis 25.11.2005, Berlin

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Different effects of sibutramin on metabolic parameters depending on different antihypertensive treatments

Einflußnahme auf metabolische Parameter unter Sibutramin durch unterschiedliche antihypertensive Kombinationstherapien

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  • J. Scholze - Charité - Universitätsmedizin Berlin, Campus Mitte, Berlin (Berlin, D)
  • D. Herrmann - Charité - Universitätsmedizin Berlin, Campus Mitte, Berlin (Berlin, D)

Hypertonie 2005. 29. Wissenschaftlicher Kongress der Deutschen Hochdruckliga. Berlin, 23.-25.11.2005. Düsseldorf, Köln: German Medical Science; 2006. Doc05hochP132

The electronic version of this article is the complete one and can be found online at: http://www.egms.de/en/meetings/hoch2005/05hoch132.shtml

Published: August 8, 2006

© 2006 Scholze et al.
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by-nc-nd/3.0/deed.en). You are free: to Share – to copy, distribute and transmit the work, provided the original author and source are credited.

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Weight reduction lead generally to a substancial improvement of the carbohydrate and lipid metabolism. This is also seen by the serotonin- and norepinephrine reuptake inhibitor sibutramine (sib). On the other hand it is unknown if various antihypertensive combination regimes can influence these effects.

In a randomizec, doubleblind multicenter study with 169 obese hypertensive patients we investigated the sib (10/15 mg/d) vs placebo effects on metabolic parameters in 3 groups treated by 3 different antihypertensive regimes (A: ramipril plus felodipine ER 5/5 mg, B: trandolapril plus verapamil SR 2/180 mg, C: metoprolol plus HCT 95/12.5 mg).

The weight reduction was significant higher in the groups A and B, treated with ACEI/calciumantagonist combinations (-6.7, -6.0 %) compared to group C treated with betablocker and diuretic (-3.3 %). The effects of sib on metabolic parameters in these different groups are listed in Table 1 [Tab. 1].

Conclusion: Compared to ACEI/calciumantagonist combinations the betablocker/diuretic combination showed unfavourable effects especially in regard to the carbohydrate metabolism and weight reduction in obese hypertensive patients treated with sib.