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29. Wissenschaftlicher Kongress der Deutschen Hochdruckliga

Deutsche Hochdruckliga e. V. DHL ® - Deutsche Hypertonie Gesellschaft Deutsches Kompetenzzentrum Bluthochdruck

23. bis 25.11.2005, Berlin

Different effects of sibutramin on metabolic parameters depending on different antihypertensive treatments

Einflußnahme auf metabolische Parameter unter Sibutramin durch unterschiedliche antihypertensive Kombinationstherapien

Meeting Abstract

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  • J. Scholze - Charité - Universitätsmedizin Berlin, Campus Mitte, Berlin (Berlin, D)
  • D. Herrmann - Charité - Universitätsmedizin Berlin, Campus Mitte, Berlin (Berlin, D)

Hypertonie 2005. 29. Wissenschaftlicher Kongress der Deutschen Hochdruckliga. Berlin, 23.-25.11.2005. Düsseldorf, Köln: German Medical Science; 2006. Doc05hochP132

The electronic version of this article is the complete one and can be found online at:

Published: August 8, 2006

© 2006 Scholze et al.
This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( You are free: to Share – to copy, distribute and transmit the work, provided the original author and source are credited.



Weight reduction lead generally to a substancial improvement of the carbohydrate and lipid metabolism. This is also seen by the serotonin- and norepinephrine reuptake inhibitor sibutramine (sib). On the other hand it is unknown if various antihypertensive combination regimes can influence these effects.

In a randomizec, doubleblind multicenter study with 169 obese hypertensive patients we investigated the sib (10/15 mg/d) vs placebo effects on metabolic parameters in 3 groups treated by 3 different antihypertensive regimes (A: ramipril plus felodipine ER 5/5 mg, B: trandolapril plus verapamil SR 2/180 mg, C: metoprolol plus HCT 95/12.5 mg).

The weight reduction was significant higher in the groups A and B, treated with ACEI/calciumantagonist combinations (-6.7, -6.0 %) compared to group C treated with betablocker and diuretic (-3.3 %). The effects of sib on metabolic parameters in these different groups are listed in Table 1 [Tab. 1].

Conclusion: Compared to ACEI/calciumantagonist combinations the betablocker/diuretic combination showed unfavourable effects especially in regard to the carbohydrate metabolism and weight reduction in obese hypertensive patients treated with sib.