gms | German Medical Science

29. Wissenschaftlicher Kongress der Deutschen Hochdruckliga

Deutsche Hochdruckliga e. V. DHL ® - Deutsche Hypertonie Gesellschaft Deutsches Kompetenzzentrum Bluthochdruck

23. bis 25.11.2005, Berlin

Influence of Cardiac Hemodynamic Parameters on Coronary Artery Opacification with 64-slice CT

64-Zeilen CT: Einfluss von hämodynamischen Parametern auf die Kontrastmitteldichte in Koronararterien

Meeting Abstract

  • L. Husmann - Universitätsspital Zürich (Zürich, CH)
  • L. Leschka - Universitätsspital Zürich (Zürich, CH)
  • H. Alkadhi - Universitätsspital Zürich (Zürich, CH)
  • S. Wildermuth - Universitätsspital Zürich (Zürich, CH)
  • L. Desbiolles - Universitätsspital Zürich (Zürich, CH)

Hypertonie 2005. 29. Wissenschaftlicher Kongress der Deutschen Hochdruckliga. Berlin, 23.-25.11.2005. Düsseldorf, Köln: German Medical Science; 2006. Doc05hochP122

The electronic version of this article is the complete one and can be found online at:

Published: August 8, 2006

© 2006 Husmann et al.
This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( You are free: to Share – to copy, distribute and transmit the work, provided the original author and source are credited.



Purpose: To evaluate the influence of the ejection fraction (EF), stroke volume (SV), heart rate, and cardiac output (CO) on coronary artery opacification with 64-slice computed tomography (CT).

Materials and Methods: 60 patients (22 women, 38 men; mean age 61.9±10.5 years) underwent retrospectively electrocardiography (ECG)-gated 64-slice CT coronary angiography. Ten data sets were reconstructed in 10% steps of the R-R interval for quantification of left ventricular EF, SV, and CO using a software capable of semi-automated contour detection. Attenuation values were measured and contrast-to-noise ratios (CNR) were calculated in the proximal right coronary artery (RCA) and left main artery (LMA). CNR was defined as difference of mean density in the vessel from the mean density in perivascular tissue divided by image noise in the ascending aorta.

Results: The mean EF was 61.5 ± 12.4%, SV was 63.2±15.6ml, heart rate was 62.5 ± 11.8 bpm, and the CO was 3.88 ± 1.06 L/min. Attenuation in the LMA was 341 ± 71 HU and 322 ± 73 HU in the RCA, CNR in the LMA was 17.8 ± 4.6 and 17.2 ± 4.4 in the RCA. No significant correlation was present between both the EF and heart rate and the attenuation and CNR in the RCA and LMA. A significant negative correlation was found between the SV and attenuation (r = -0.26, P < 0.05) and CNR (r = -0.26, P < 0.05) in the RCA and LMA (r = -0.34, P < 0.01 and r = -0.26, P < 0.05, respectively). Similarly, a significant negative correlation was found between the CO and attenuation (r = -0.42, P < 0.003) and CNR in the RCA (r = -0.39, P < 0.003) and LMA (r= -0.56, P < 0.001 and r = -0.44, P < 0.001, respectively).

Conclusions: The actual hemodynamic status of the patient influences the coronary artery opacification with 64-slice CT, in that vessel opacification decreases as SV and CO increases.