gms | German Medical Science

29. Wissenschaftlicher Kongress der Deutschen Hochdruckliga

Deutsche Hochdruckliga e. V. DHL ® - Deutsche Hypertonie Gesellschaft Deutsches Kompetenzzentrum Bluthochdruck

23. bis 25.11.2005, Berlin

Non-invasive coronary angiography: Diagnostic accuracy of 64-slice multi-detector row CT in 106 patients

Nicht-invasive Koronardiagnostik: Genauigkeit der 64-Zeilen CT Koronarangiographie in 106 Patienten

Meeting Abstract

  • S. Leschka - Universitätsspital Zürich (Zürich, CH)
  • H. Alkadhi - Universitätsspital Zürich (Zürich, CH)
  • L. Husmann - Universitätsspital Zürich (Zürich, CH)
  • A. Plass - Universitätsspital Zürich (Zürich, CH)
  • B. Marincek - Universitätsspital Zürich (Zürich, CH)
  • S. Wildermuth - Universitätsspital Zürich (Zürich, CH)

Hypertonie 2005. 29. Wissenschaftlicher Kongress der Deutschen Hochdruckliga. Berlin, 23.-25.11.2005. Düsseldorf, Köln: German Medical Science; 2006. Doc05hochP119

The electronic version of this article is the complete one and can be found online at:

Published: August 8, 2006

© 2006 Leschka et al.
This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( You are free: to Share – to copy, distribute and transmit the work, provided the original author and source are credited.



Purpose: Comparison of the diagnostic accuracy of 64-slice CT coronary angiography (CTA) with that of invasive coronary angiography (ICA) in detection of coronary artery stenosis.

Materials and Methods: We prospectively studied 106 patients (39 women, 67 men; mean age 60.9±10.3 years) with suspected coronary artery disease who underwent both 64-slice multi-detector row CTA and ICA (mean heart rate 64.6±13.4 beats per minute, range 38-99). Scanning parameters were: slice acquisition 64x0.6 mm, gantry rotation time 370 ms, 650-850 mAs, 120 kV. Exclusion criteria for CT were: arrhythmia, previous allergic reactions to iodine contrast media, severe renal insufficiency, and previous percutaneous transluminal coronary stent placement. The coronary artery tree was divided into 15 segments and all segments ³1.5 mm were considered for assessment of significant coronary stenosis (diameter reduction >50%).

Results: Significant coronary stenosis was present in 63 patients (59%) with a total of 229 of 1590 segments being stenosed (14%), and non-significant disease or normal coronary arteries in 43 patients (41%). None of the coronary segments needed to be excluded from analysis. Overall sensitivity, specificity, positive predictive value and negative predictive value for classifying stenoses were 94%, 97%, 86% and 99%, respectively.

Conclusions: 64-slice multi-detector row CTA of the coronary arteries reliably and accurately detects or excludes significant coronary artery stenosis