gms | German Medical Science

28. Wissenschaftlicher Kongress der Deutschen Hochdruckliga

24. bis 27.11.2004, Hannover

Endothelial damage caused by ageing measured by Retinal Vessel Analyzer

Retinale Gefäßdarstellung mittels Retinal Vessel Analyzer zur Charakterisierung des Endothelschadens durch Altern

Meeting Abstract (Hypertonie 2004)

  • K.E. Kotliar - Technische Universität Ilmenau (Ilmenau, D)
  • B. Mücke - Technische Universität Ilmenau (Ilmenau, D)
  • W. Vilser - Technische Universität München (München, D)
  • I. Lanzl - Technische Universität München (München, D)

Hypertonie 2004. 28. Wissenschaftlicher Kongress der Deutschen Hochdruckliga. Hannover, 24.-27.11.2004. Düsseldorf, Köln: German Medical Science; 2005. Doc04hochP60

The electronic version of this article is the complete one and can be found online at:

Published: August 10, 2005

© 2005 Kotliar et al.
This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( You are free: to Share – to copy, distribute and transmit the work, provided the original author and source are credited.



Background: The ocular fundus offers the unique non invasive possibility to visualize vessels. By image analysis it is possible to perceive vessels in their dynamic state online. The different vessel widths can be characterized along a given vessel segment.

Methods: 10 healthy volunteers of the age group of 20-30 years and 60-70 years each were examined for 2 minutes by retinal vessel analyser (RVA / Fa. IMEDOS, Jena). In arterial segments of a length of approximately 1,5 mm vessel diameters were measured. Differences in amplitude and frequency of vessel widths change was characterized by the calculated parameter: SEF (spectral end frequency).

Results: SEF was statistically significantly different in both examined age groups (0.102 +/- 0.030 in young volunteers and 0.146 +/- 0.040 in the elderly group).

Discussion: Retinal branch vessels possess alternating vessel diameters. Using the retinal vessel analyser the frequency and amplitude of diameter differences can be assessed. We describe the parameter SEF, which we termed 'vessel thickness frequency change'. In the group of older volunteers this parameter is significantly different from younger volunteers. This means, that vessels in the elderly assume a less regular profile. We think this might be an expression of endothelial damage.