gms | German Medical Science

27. Wissenschaftlicher Kongress der Deutschen Hochdruckliga

Deutsche Liga zur Bekämpfung des hohen Blutdrucks – Deutsche Hypertonie Gesellschaft e. V.

26. bis 29.11.2003, Bonn

Limited effects of sympathoexcitation on parameters of haemostasis in primary hypertensive subjects

Limitierte Effekte von Sympathoexzitation auf das Hämostasesystem bei primären Hypertonikern

Meeting Abstract (Hypertonie 2003)

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  • J. Struck - Lübeck, D
  • H. Fehm - Lübeck, D
  • C. Dodt - Lübeck, D

Hypertonie 2003. 27. Wissenschaftlicher Kongress der Deutschen Hochdruckliga. Bonn, 26.-29.11.2003. Düsseldorf, Köln: German Medical Science; 2004. Doc03hochP89

The electronic version of this article is the complete one and can be found online at:

Published: November 11, 2004

© 2004 Struck et al.
This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( You are free: to Share – to copy, distribute and transmit the work, provided the original author and source are credited.




To investigate the relationship between sympathetic activation and fibrinolytic activity. We tested the effects of three standardized sympathoexcitatory maneuvers on different haemostatic parameters in hypertensive subjects.

Design and methods

18 hypertensive otherwise healthy subjects without antihypertensive drugs were examined. Three consecutive sympathoexcitatory maneuvers were performed (lower body negative pressure 10 min (LBNP), cold pressor 1,5 min, hyperinsulinemic euglycemic clamp 60 min). Sympathoexcitation was quantified by microneurographic recording of muscle sympathetic nerve activity (MSNA). Additionally blood pressure and heart rate were measured. Blood was drawn to determine levels of epinephrine, norepinephrine, tissue plasminogen activator (t-PA), t-PA complexed with plasminogen activator inhibitor type 1 (t-PA/PAI), thrombin-antithrombin III complex (TAT), prothrombin fragment 1+2 (F1+2) and D-Dimer. Data are expressed as mean ± SEM.

[Tab. 1]


All three sympathoexcitatory maneuvers significantly increased MSNA with no difference in effect. Only the cold pressor test exerts significant effects on t-PA and TAT.


Standardized maneuvers to induce sympathoexcitation of similar strength evoke differential effects on haemostasis. Significant effects were only observed during the painful cold pressor test. This suggests that sympathoexcitation per se exerts only limited effects on haemostatic parameters in vivo.