Article
Limited effects of sympathoexcitation on parameters of haemostasis in primary hypertensive subjects
Limitierte Effekte von Sympathoexzitation auf das Hämostasesystem bei primären Hypertonikern
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Authors
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J. Struck
- Lübeck, D
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H. Fehm
- Lübeck, D
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C. Dodt
- Lübeck, D
| Published: | November 11, 2004 |
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Outline
Text
Objective
To investigate the relationship between sympathetic activation and fibrinolytic activity. We tested the effects of three standardized sympathoexcitatory maneuvers on different haemostatic parameters in hypertensive subjects.
Design and methods
18 hypertensive otherwise healthy subjects without antihypertensive drugs were examined. Three consecutive sympathoexcitatory maneuvers were performed (lower body negative pressure 10 min (LBNP), cold pressor 1,5 min, hyperinsulinemic euglycemic clamp 60 min). Sympathoexcitation was quantified by microneurographic recording of muscle sympathetic nerve activity (MSNA). Additionally blood pressure and heart rate were measured. Blood was drawn to determine levels of epinephrine, norepinephrine, tissue plasminogen activator (t-PA), t-PA complexed with plasminogen activator inhibitor type 1 (t-PA/PAI), thrombin-antithrombin III complex (TAT), prothrombin fragment 1+2 (F1+2) and D-Dimer. Data are expressed as mean ± SEM.
Results
All three sympathoexcitatory maneuvers significantly increased MSNA with no difference in effect. Only the cold pressor test exerts significant effects on t-PA and TAT.
Conclusions
Standardized maneuvers to induce sympathoexcitation of similar strength evoke differential effects on haemostasis. Significant effects were only observed during the painful cold pressor test. This suggests that sympathoexcitation per se exerts only limited effects on haemostatic parameters in vivo.
