gms | German Medical Science

27. Wissenschaftlicher Kongress der Deutschen Hochdruckliga

Deutsche Liga zur Bekämpfung des hohen Blutdrucks – Deutsche Hypertonie Gesellschaft e. V.

26. bis 29.11.2003, Bonn

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Intensive 1-year lifestyle modification improves microvascular endothelial function in CAD patients

Intensive Lebensstilmodifikation über 1 Jahr verbessert die mikrovaskuläre Endothelfunktion bei KHK-Patienten

Meeting Abstract (Hypertonie 2003)

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  • presenting/speaker N.T.M. Knoblauch - Kliniken Essen-Mitte, Universitätsklinikum Essen (Essen, D)
  • A. Michalsen - Kliniken Essen-Mitte, Universitätsklinikum Essen (Essen, D)
  • T. Philipp - Kliniken Essen-Mitte, Universitätsklinikum Essen (Essen, D)
  • G.J. Dobos - Kliniken Essen-Mitte, Universitätsklinikum Essen (Essen, D)
  • R.R. Wenzel - Kliniken Essen-Mitte, Universitätsklinikum Essen (Essen, D)

Hypertonie 2003. 27. Wissenschaftlicher Kongress der Deutschen Hochdruckliga. Bonn, 26.-29.11.2003. Düsseldorf, Köln: German Medical Science; 2004. Doc03hochP59

The electronic version of this article is the complete one and can be found online at: http://www.egms.de/en/meetings/hoch2003/03hoch159.shtml

Published: November 11, 2004

© 2004 Knoblauch et al.
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by-nc-nd/3.0/deed.en). You are free: to Share – to copy, distribute and transmit the work, provided the original author and source are credited.

Outline

Text

Objective

In patients with coronary artery disease (CAD) endothelial function is impaired and correlates with morbidity and mortality. We examined the effect of an intensive lifestyle modification program over one year on endothelial function in CAD patients.

Materials and methods

We investigated the effects of acetylcholine (ACh 10-9-10-7 mol) induced vasodilatation as well as the effects of NO-synthase inhibitor L-NMMA (10-8 mol) vasoconstriction in the forearm skin microcirculation of 17 CAD patients and 12 healthy volunteers, using the double injection technique and laser Doppler imaging. The results are expressed in perfusion units (PU) as differences from saline in mean ± S.E.M.; the area under the time-response-curve was calculated (AUC). Measurements were performed at baseline and after one year of intensive lifestyle modification.

Results

Vasodilatation to ACh (10-9-10-7 mol) was significantly reduced in CAD patients compared to healthy volunteers (p<0.001). After one year of intensive lifestyle modification CAD patients showed a significant improvement of vasodilatation to ACh (p<0.001 versus baseline). The L-NMMA (10-8 mol) induced vasoconstriction was significantly reduced after one year of intensive lifestyle modification (p<0.05 versus baseline).

Conclusion

Comprehensive and intensive 1-year lifestyle modification improves endothelial function in CAD patients. Laser Doppler imaging is a new method to assess the effects of cardiovascular intervention on endothelial function [Fig. 1].