gms | German Medical Science

27. Wissenschaftlicher Kongress der Deutschen Hochdruckliga

Deutsche Liga zur Bekämpfung des hohen Blutdrucks – Deutsche Hypertonie Gesellschaft e. V.

26. bis 29.11.2003, Bonn

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Congenital oligonephropathy deteriorates development of hypertension and albuminuria due to renal mass reduction

Kongenitale Oligonephronie erhöht den arteriellen Blutdruck und die Albuminurie nach Nierenteilresektion

Meeting Abstract (Hypertonie 2003)

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  • presenting/speaker I. Bauhaus - Charité / B.-Franklin (Berlin, D)
  • M. Lorenz - Charité / B.-Franklin (Berlin, D)
  • J. Eberson - Charité / B.-Franklin (Berlin, D)
  • M. Paul - Charité / B.-Franklin (Berlin, D)
  • W. Zidek - Charité / B.-Franklin (Berlin, D)
  • R. Kreutz - Charité / B.-Franklin (Berlin, D)
  • L. Rothermund - Charité / B.-Franklin (Berlin, D)

Hypertonie 2003. 27. Wissenschaftlicher Kongress der Deutschen Hochdruckliga. Bonn, 26.-29.11.2003. Düsseldorf, Köln: German Medical Science; 2004. Doc03hochP3

The electronic version of this article is the complete one and can be found online at: http://www.egms.de/en/meetings/hoch2003/03hoch103.shtml

Published: November 11, 2004

© 2004 Bauhaus et al.
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by-nc-nd/3.0/deed.en). You are free: to Share – to copy, distribute and transmit the work, provided the original author and source are credited.

Outline

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Background

Deficit of congenital nephron number determines development of arterial hypertension in adult life. We investigated the role of congenital oligonephropathy for development of hypertension and renal function due to renal mass reduction.

Methods and Results

Munich Wistar Fömter (MWF) rats with a genetic reduction of nephron number were compared to Wistar rats with normal nephron number. At 8 weeks of age animals underwent sham-operation (sham), renal mass reduction (Nx), or Nx and treatment with the angiotensin-converting enzyme inhibitor ramipril (ACE) for 4 weeks.

Systolic blood pressure (SBP), and albuminuria (UAE), were elevated, and creatinine clearance (Ccrea) was decreased in both MWF-Nx and Wistar-Nx groups compared to their sham-operated controls (p<0.05, respectively). Dependent on nephron number, SBP, UAE, were increased, whereas Ccrea was not altered in MWF-Nx compared to Wistar-Nx (p<0.05, respectively). Treatment with ramipril in MWF-Nx-ACE and Wistar-Nx-ACE did lower SBP, UAE, and increased Ccrea compared to MWF-Nx and Wistar-Nx (p<0.05, respectively).

Conclusion

Reduced inborn nephron number deterioretes manifestation of hypertension and albuminuria due to renal mass reduction. ACE inhibition exerts antihypertensive and renoprotective effects after renal mass reduction in congenital oligonephropathy.