gms | German Medical Science

27. Wissenschaftlicher Kongress der Deutschen Hochdruckliga

Deutsche Liga zur Bekämpfung des hohen Blutdrucks – Deutsche Hypertonie Gesellschaft e. V.

26. bis 29.11.2003, Bonn

Regulation of macula densa cyclooxygenase-2 expression is not dependent on glomerular filtration

Regulation der renalen Cyclooxygenase-2 ist unabhängig von der glomerulären Filtration

Meeting Abstract (Hypertonie 2003)

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  • presenting/speaker M.C. Kammerl - Universitätsklinik Regensburg (Regensburg, D)

Hypertonie 2003. 27. Wissenschaftlicher Kongress der Deutschen Hochdruckliga. Bonn, 26.-29.11.2003. Düsseldorf, Köln: German Medical Science; 2004. Doc03hochP2

The electronic version of this article is the complete one and can be found online at:

Published: November 11, 2004

© 2004 Kammerl.
This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( You are free: to Share – to copy, distribute and transmit the work, provided the original author and source are credited.



Aim of the study was to to determine the importance of glomerular filtration for the regulation of cyclooxygenase-2 (COX-2) and of renin expression in the kidney cortex. Therefore the right ureters of male Sprague-Dawley rats were ligated for 5 weeks and hydronephrosis developed. While the cortex was still preserved a reduction of medullary mass was observed. Measurements of inulin clearance confirmed that glomerular filtration in the ligated kidney was abrogated. In animals kept under control conditions neither renocortical COX-2 nor renin gene mRNA abundance were different between the ligated and the intact kidney. Subcutaneous infusions of furosemide (12 mg/kg per day ) or treatment with low salt (0.02% w/w) in combination with the ACE-inhibitor ramipril (10 mg/kg per day) clearly stimulated the expression of COX-2 in the cortical thick ascending limbs of Henle and in the macula densa region as well as juxtaglomerular renin expression both in the intact and in the ligated kidneys.

We conclude that glomerular filtration is not essential for the regulation of COX-2 and of renin expression in the rat kidney cortex.