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82nd Annual Meeting of the German Society of Oto-Rhino-Laryngology, Head and Neck Surgery

German Society of Oto-Rhino-Laryngology, Head and Neck Surgery

01.06. - 05.06.2011, Freiburg

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Cytokine expression patterns in sera of head and neck squamous cell carcinoma patients

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  • corresponding author Gunnar Wichmann - HNO-Forschungslabor, Universität Leipzig, Leipzig
  • Carolin Körner - HNO-Forschungslabor, Universität Leipzig, Leipzig
  • Luise Meilke - HNO-Forschungslabor, Universität Leipzig, Leipzig
  • Andreas Dietz - Klinik und Poliklinik für HNO-Heilkunde, Universität Leipzig, Leipzig
  • Anett Reiche - HNO-Forschungslabor, Universität Leipzig, Leipzig
  • Kristin Herrmann - Leipzig
  • Wolfram Aust - Klinik und Poliklinik für HNO-Heilkunde, Universität Leipzig, Leipzig
  • Andreas Boehm - Klinik und Poliklinik für HNO-Heilkunde, Universität Leipzig, Leipzig

Deutsche Gesellschaft für Hals-Nasen-Ohren-Heilkunde, Kopf- und Hals-Chirurgie. 82. Jahresversammlung der Deutschen Gesellschaft für Hals-Nasen-Ohren-Heilkunde, Kopf- und Hals-Chirurgie. Freiburg i. Br., 01.-05.06.2011. Düsseldorf: German Medical Science GMS Publishing House; 2011. Doc11hnod276

doi: 10.3205/11hnod276, urn:nbn:de:0183-11hnod2764

Published: April 19, 2011

© 2011 Wichmann et al.
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Outline

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Introduction: It is known that cytokine expression in head and neck squamous cell carcinoma (HNSCC) differs from healthy mucosa. Possibly this might also be reflected in serum concentrations. Since cytokines are potential indicators of regulatory dysbalances, they might reflect the consecutive steps of cancerogenesis and the stage of disease. Consequently, it might as well be possible to subdivide HNSCC into distinct entities by patterns of cytokine levels in sera. Thus, the linkage between cytokine expression and the status of disease was analyzed in 47 HNSCC to prove their usefulness as biomarkers and to distinguish subgroups of HNSCC.

Methods: After obtaining patients’ informed consent, sera of 47 patients having oropharyngeal, hypopharyngeal or laryngeal HNSCC, and (for reference) of 63 blood donors without any malignancy (20 healthy persons, 43 with allergic or idiopathic rhinitis) were subjected to quantitation of interleukin 6 (IL-6), IL-8, and monocyte chemoattractant protein-1 (MCP-1) using OptEIA™-Kits (BD Bioscience).

Results: Levels of IL-6, IL-8, and MCP-1 indicated clear differences between sera of patients with or without HNSCC and as well stage dependent differences in HNSCC. Cytokine patterns and in particular concentrations of IL-6 correlate with tumor status and aggressiveness of the disease. A clear discrimination between HNSCC patients and the reference group (healthy and allergic persons) by MCP-1 concentrations in sera was possible.

Conclusion: The data for the first time suggests the expression pattern of IL-6, IL-8 and MCP-1 as possible biomarker in HNSCC. However, this should be confirmed within a greater HNSCC cohort.