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80th Annual Meeting of the German Society of Oto-Rhino-Laryngology, Head and Neck Surgery

German Society of Oto-Rhino-Laryngology, Head and Neck Surgery

20.05. - 24.05.2009, Rostock

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Prognostic value of HPV-state and cervical metastasis in tonsillar carcinomas

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  • corresponding author Jos Straetmans - Maastricht University Medical Centre, Maastricht, Netherlands
  • Nadine Olthof - Maastricht University Medical Centre, Maastricht, Netherlands
  • Ilse Vos - Maastricht University Medical Centre, Maastricht, Netherlands
  • Jos de Jong - Maastricht Radiation Oncology Hospital, Maastricht, Netherlands
  • Ernstjan Speel - Maastricht University Medical Centre, Maastricht, Netherlands
  • Bernd Kremer - Maastricht University Medical Centre, Maastricht, Netherlands

Deutsche Gesellschaft für Hals-Nasen-Ohren-Heilkunde, Kopf- und Hals-Chirurgie. 80. Jahresversammlung der Deutschen Gesellschaft für Hals-Nasen-Ohren-Heilkunde, Kopf- und Hals-Chirurgie. Rostock, 20.-24.05.2009. Düsseldorf: German Medical Science GMS Publishing House; 2009. Doc09hnod450

doi: 10.3205/09hnod450, urn:nbn:de:0183-09hnod4505

Published: April 17, 2009

© 2009 Straetmans et al.
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Outline

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Objective: Determination of the controversial prognostic value of nodal state in tonsillar squamous cell carcinomas (TSCC), dependent on HPV-state and different treatment modalities.

Material and method: Retrospective analysis of disease-free, disease-specific and overall survival of 81 patients with TSCC, related to integration of HPV-DNA in the genome (detected with FISH) and to nodal status and corrected for other clinical parameters.

Results: 41% of TSCCs were positive for HPV type 16. In these TSCCs, the primary tumour was significantly smaller (p=0,04), without differences in cervical metastasis (p=0,204) compared to HPV-negative TSCCs. TSCCs associated with HPV were more often treated with radical surgery + radiotherapy. Nodal state did not (NS), and HPV-state did influence the prognosis (p=0,02). However within each treatment modality, HPV- and nodal status were no prognostic indicators.

Conclusion: In TSCCs, HPV- and nodal status seem not to influence prognosis within each treatment modality. HPV-positive TSCCs seem to metastasize to cervical lymph nodes at less advanced T-stages. The prognostic value of N-status in TSCCs is probably diminished by the presence of HPV.