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78th Annual Meeting of the German Society of Oto-Rhino-Laryngology, Head and Neck Surgery

German Society of Oto-Rhino-Laryngology, Head and Neck Surgery

16.05. - 20.05.2007, Munich

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IL-6 production from monocytes is correlated with worsened survival in Head and Neck Squamous Cell Carcinomas

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  • corresponding author Kenneth W. Kross - Department of Otolaryngology/Head and Neck Surgery, Maastricht, The Netherlands
  • John Helge Heimdal - Department of Otolaryngology/Head and Neck Surgery, Bergen, Norway
  • Carla Olsnes - Department of Otolaryngology/Head and Neck Surgery, Bergen, Norway
  • Jan Olofsson - Department of Otolaryngology/Head and Neck Surgery, Bergen, Norway
  • Hans Joergen Aarstad - Department of Otolaryngology/Head and Neck Surgery, Bergen, Norway

Deutsche Gesellschaft für Hals-Nasen-Ohren-Heilkunde, Kopf- und Hals-Chirurgie. 78. Jahresversammlung der Deutschen Gesellschaft für Hals-Nasen-Ohren-Heilkunde, Kopf- und Hals-Chirurgie e.V.. München, 16.-20.05.2007. Düsseldorf: German Medical Science GMS Publishing House; 2007. Doc07hnod141

The electronic version of this article is the complete one and can be found online at: http://www.egms.de/en/meetings/hnod2007/07hnod141.shtml

Published: April 24, 2007

© 2007 Kross et al.
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by-nc-nd/3.0/deed.en). You are free: to Share – to copy, distribute and transmit the work, provided the original author and source are credited.

Outline

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Introduction: Head and Neck Squamous Cell Carcinomas (HNSCC) are infiltrated with cells from the Mononuclear phagocyte system (MNP) which have the ability to bind and, if activated, kill tumor cells. IL-6 and MCP-1 are cytokines which play a role in the development and metastasis of cancer.

Methods: An organ culture method was used by which small parts of tissues, either from Head and Neck Squamous Carcinoma (HNSCC) or benign mucosa, could be maintained viable in vitro as Fragment (F)-spheroids. F-spheroids stimulate autologous monocytes to secrete interleukin (IL)-6 and monocyte chemotactic protein (MCP)-1 in vitro. We analysed the IL-6 and MCP-1 production from monocytes in co-culture with autologous F-spheroids in a cohort of patients from 1998-2005 all treated for HNSCC.

Results: We found that an increased production of IL-6 by autologous monocytes, in co-culture with F-spheroids is correlated with recurrence of disease(p<0,05).

Conclusion: Monocytes in co-culture with autologous F-spheroids produce IL-6 and MCP-1. The IL-6 production is shown to be a prognostic factor in vitro in HNSCC.

Unterstützt durch: University in Bergen, Norway