gms | German Medical Science

77th Annual Meeting of the German Society of Oto-Rhino-Laryngology, Head and Neck Surgery

German Society of Oto-Rhino-Laryngology, Head and Neck Surgery

24.05. - 28.05.2006, Mannheim

Increase in the safety margin by BGP-15 of cisplatin in the guinea pig

Meeting Abstract

  • corresponding author Tamas Racz - Univ. Klinik für HNOKHC, Debrecen, Ungarn
  • Judit Szilvassy - Univ. Klinik für HNOKHC, Debrecen, Ungarn
  • Istvan Sziklai - Univ. Klinik für HNOKHC, Debrecen, Ungarn
  • Gyorgy Rabloczky - N-Gene Laboratories, Budapest, Ungarn
  • Zoltan Szilvassy - Institut für Pharmakologie, Debrecen, Ungarn

Deutsche Gesellschaft für Hals-Nasen-Ohren-Heilkunde, Kopf- und Hals-Chirurgie. 77. Jahresversammlung der Deutschen Gesellschaft für Hals-Nasen-Ohren-Heilkunde, Kopf- und Hals-Chirurgie e.V.. Mannheim, 24.-28.05.2006. Düsseldorf, Köln: German Medical Science; 2006. Doc06hnod198

The electronic version of this article is the complete one and can be found online at:

Published: April 24, 2006

© 2006 Racz et al.
This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( You are free: to Share – to copy, distribute and transmit the work, provided the original author and source are credited.



Objectives: The aim of this study was to investigate the effect of the BGP-15 cisplatin-induced experimental neuropathy in a subacute treatment schedule in guinea pigs. Neuropathy was characterized by the changes of objective hearing threshold and interpeak latency. Study design: short communication.

Methods: The neuroprotective effect of BGP-15 against peripheral sensory neuropathy was studied in guinea pigs exposed to short-term cisplatin administration. Changes in ABR threshold and interpeak latencies were determind after short term treating the animals either cisplatin, cisplatin+BGP-15 and cisplatin+placebo.

Results: Electrophysiological recordings were carried out by stimulating the acoustic nerve. BGP-15 couldn't protect increase of hearing thresholds, but decreased the interpeak latency I.-V. on BERA.

Conclusions: Our in vivo studies have demonstrated that BGP-15 protected auditory neurons from the toxic effects of cisplatin. This chemoprotective potential of BGP-15 could be well correlated with its PARP-inhibitory effect and its ability to protect against the damages induced by the increased level of reactive oxygen species (ROS) in response to anti-cancer treatment.

Key words: toxic effects of antitumor drugs, peripheral sensory neuropathy, prevention of neuropathy, nerve conduction velocity, poly- (ADP-ribose)-polymerase (PARP) enzyme, modulation of PARP activity, BGP-15, cisplatin.