gms | German Medical Science

83rd Annual Meeting of the German Society of Oto-Rhino-Laryngology, Head and Neck Surgery

German Society of Oto-Rhino-Laryngology, Head and Neck Surgery

16.05. - 20.05.2012, Mainz

Dysregulated expression of proteinase inhibitor in the pathogenesis of chronic rhinosinusitis

Meeting Abstract

  • corresponding author Kai Fruth - Univ. HNO-Klinik, Mainz, Germany
  • presenting/speaker Gyula Göbel - Bürgerspital, Solothurn, Germany
  • presenting/speaker Jan Gosepath - HSK-Klinik, HNO-Abt., Wiesbaden, Germany
  • presenting/speaker Irene Schmidtmann - IMBEI der Universitätsmedizin, Mainz, Germany
  • presenting/speaker Wolf J. Mann - Univ. HNO-Klinik, Mainz, Germany
  • presenting/speaker Jürgen Brieger - Univ. HNO-Klinik, Mainz, Germany

German Society of Oto-Rhino-Laryngology, Head and Neck Surgery. 83rd Annual Meeting of the German Society of Oto-Rhino-Laryngology, Head and Neck Surgery. Mainz, 16.-20.05.2012. Düsseldorf: German Medical Science GMS Publishing House; 2012. Doc12hno04

DOI: 10.3205/12hno04, URN: urn:nbn:de:0183-12hno042

Published: July 23, 2012

© 2012 Fruth et al.
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by-nc-nd/3.0/deed.en). You are free: to Share – to copy, distribute and transmit the work, provided the original author and source are credited.


Outline

Text

Background: Chronic Rhinosinusitis is a multifactorial disease. An altered epithelial function might be one of the factors contributing to the pathophysiology of chronic rhinosinusitis. Spink5 is a protease inhibitor and supposed to be an essential regulator of epithelial integrity. The role of spink5 expression in the pathophysiology of CRS with (CRSwNP) and without nasal polyps (CRSsNP) regarding allergic sensitivity, bronchial asthma and aspirin intolerance is unknown.

Material & Methods: 15 nasal mucosa samples were taken during sinus surgery from individuals with CRSsNP, 59 from patients with CRSwNP, and 30 healthy tissue controls of the inferior turbinate. 36 of these individuals were suffering from allergies, 22 from bronchial asthma, and 18 from aspirin intolerance. All samples were analyzed for their individual spink5 status by polymerase chain reaction.

Results: Spink5 expression levels were decreased in individuals with CRSwNP, especially in those with aspirin intolerance and in individuals with allergies.

Conclusion: Lowered spink5 expression might lead to an altered epithelial barrier function and might be another potential aspect of the pathophysiology of CRS characteristic for aspirin intolerance and allergic sensitivity.