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80th Annual Meeting of the German Society of Oto-Rhino-Laryngology, Head and Neck Surgery

German Society of Oto-Rhino-Laryngology, Head and Neck Surgery

20.05. - 24.05.2009, Rostock

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Dysbalance of expression of cyclooxygenases – a possible key role in the pathogenesis of nasal polyposis

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  • corresponding author Kai Fruth - Hals-, Nasen-, Ohrenklinik und Poliklinik Mainz, Mainz, Germany
  • Chengjing Zhu - Hals-, Nasen-, Ohrenklinik und Poliklinik Mainz, Mainz, Germany
  • Juergen Brieger - Hals-, Nasen-, Ohrenklinik und Poliklinik Mainz, Mainz, Germany
  • Wolf Mann - Hals-, Nasen-, Ohrenklinik und Poliklinik Mainz, Mainz, Germany

German Society of Oto-Rhino-Laryngology, Head and Neck Surgery. 80th Annual Meeting of the German Society of Oto-Rhino-Laryngology, Head and Neck Surgery. Rostock, 20.-24.05.2009. Düsseldorf: German Medical Science GMS Publishing House; 2009. Doc09hno099

doi: 10.3205/09hno099, urn:nbn:de:0183-09hno0994

Published: July 22, 2009

© 2009 Fruth et al.
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by-nc-nd/3.0/deed.en). You are free: to Share – to copy, distribute and transmit the work, provided the original author and source are credited.

Outline

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Introduction: It is to assume that cyclooxygenases play a decisive role in the pathogenesis of nasal polyposis.

Cyclooxygenases 1 (Cox-1) and 2 (Cox-2) are relevant in arachidonic acid metabolism and are therefore essential for the synthesis of prostaglandins.

However, it s still unknown in which extent a different expression of the cyclooxygenases has an impact on the responsible pathomachanism of polyposis nasi.

Methods: 87 tissue surgical specimens were immunohistochemically labeled for Cox-1 and Cox-2. These specimens were taken from patients with nasal obstruction without inflammatory disease during turbinate surgery and from patients suffering from chronic rhinosinusitis with polyposis. Staining intensities were semiquantitatively estimated and statistically analyzed.

Results: In nasal polyps the expression of Cox-1 was significantly higher than in specimens without inflammatory disease. On the other hand Cox 2 expression was labelled similarly in nasal polyps and in specimens without inflammatory disease.

Conclusion: These data show a dysbalance of Cox expression in nasal polyps. This dysbalance might play a key role in the pathogenesis of nasal polyposis.