gms | German Medical Science

79th Annual Meeting of the German Society of Oto-Rhino-Laryngology, Head and Neck Surgery

German Society of Oto-Rhino-Laryngology, Head and Neck Surgery

30.04. - 04.05.2008, Bonn

Local botulinum toxin therapy for treatment of tardive tongue dyskinesia

Meeting Abstract

  • corresponding author Eike Krause - ENT LMU, Munich, Germany
  • Kai Bötzel - Neurology LMU, Munich, Germany
  • Johannes Hennings - Psychiatry MPI, Munich, Germany
  • Thomas Wetter - Psychiatry MPI, Munich, Germany
  • Robert Gürkov - ENT LMU, Munich, Germany

German Society of Oto-Rhino-Laryngology, Head and Neck Surgery. 79th Annual Meeting of the German Society of Oto-Rhino-Laryngology, Head and Neck Surgery. Bonn, 30.04.-04.05.2008. Düsseldorf, Köln: German Medical Science; 2008. Doc08hno73

The electronic version of this article is the complete one and can be found online at: http://www.egms.de/en/meetings/hno2008/08hno73.shtml

Published: July 8, 2008

© 2008 Krause et al.
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Outline

Text

Tardive dyskinesia (TD) is a severe side effect of antipsychotic medication. Recommended treatments for TD are not always successful and can be associated with additional adverse reactions. We report a case of a 28 years old man suffering from a severe TD of the tongue secondary to an antipsychotic medication five years ago. The pronounced tongue protrusion produced mainly speech problems and psychosocial problems. Several treatment options including clozapine, aripiprazole, ziprasidone, tiapride and clonazepam failed to improve the symptoms. Bilateral Injection of 50 U of botulinum toxin A (Dysport®, 200 U/ml) into genioglossal muscle dramatically improved tongue protrusion within three days. The effect lasted for four month and was successfully repeated afterwards. The local botulinum toxin injection is a modern and well-tolerated treatment option for the TD of the tongue.