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79th Annual Meeting of the German Society of Oto-Rhino-Laryngology, Head and Neck Surgery

German Society of Oto-Rhino-Laryngology, Head and Neck Surgery

30.04. - 04.05.2008, Bonn

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Results of ten years therapy of laryngeal carcinomas

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  • corresponding author Jan Heidemann - Department of otorhinolaryngology, head and neck surgery, Halle, Germany
  • author Kerstin Neumann - Department of otorhinolaryngology, head and neck surgery, Halle, Germany
  • author Annette Sandner - Department of otorhinolaryngology, head and neck surgery, Halle, Germany

German Society of Oto-Rhino-Laryngology, Head and Neck Surgery. 79th Annual Meeting of the German Society of Oto-Rhino-Laryngology, Head and Neck Surgery. Bonn, 30.04.-04.05.2008. Düsseldorf, Köln: German Medical Science; 2008. Doc08hno40

The electronic version of this article is the complete one and can be found online at: http://www.egms.de/en/meetings/hno2008/08hno40.shtml

Published: July 8, 2008

© 2008 Heidemann et al.
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Background: Therapy of laryngeal carcinomas has changed over the last years. Localised stages of cancer are treated almost exclusively by laser-surgery. The larynx-preserving primary Radio-Chemotherapy is increasingly used in the treatment of advanced tumors.

Material and Methods: In a retrospective study from 1996 to 2006 all patients with the diagnosis of a laryngeal carcinoma have been evaluated regarding the overall survival. A total number of 260 patients (237 men and 23 women) with a mean age of 60 years was analysed. 53,2% of the patients had glottic and 26,4% supraglottic carcinomas.20,4 % of the cancers showed advanced stages with transglottic infiltration or extension beyond the larynx. At the time of diagnosis 49% of the tumors were distributed to stage T I–II and 51% to stage T III–IV.

Results: The 5 year overall survival rate added up to 92%, 70%, 62% and 40% in stage T I, II, III, IV, respectively. Peri- or postoperative complications have been recorded in 4,6% of the patients. Frequently these occurred in consequence to co-morbidity (metabolic syndrome, detoxication of alcohol). Recurrent disease occurred in 23,4% of the patients, half of it appeared as local relapse and regional/systemic metastases, respectively.

Conclusion: Prospective studies are needed to elucidate the potential of multimodal therapies to improve the overall survival of laryngeal carcinomas.