gms | German Medical Science

76th Annual Meeting of the German Society of Oto-Rhino-Laryngology, Head and Neck Surgery

German Society of Oto-Rhino-Laryngology, Head and Neck Surgery

04.05. - 08.05.2005, Erfurt

Up-regulation of beta-catenin in external auditory canal cholesteatoma

Meeting Abstract

  • corresponding author Alexander Sauter - Universitäts-HNO-Klinik, Mannheim, Germany
  • Ramin Naim - Universitäts-HNO-Klinik, Mannheim, Germany
  • Christine Bayerl - Universitäts-Hautklinik Mannheim, Mannheim
  • Frank Riedel - Universitäts-HNO-Klinik, Mannheim, Germany
  • Karl Hoermann - Universitäts-HNO-Klinik, Mannheim, Germany

Deutsche Gesellschaft für Hals-Nasen-Ohren-Heilkunde, Kopf- und Hals-Chirurgie. 76. Jahresversammlung der Deutschen Gesellschaft für Hals-Nasen-Ohren-Heilkunde, Kopf- und Hals-Chirurgie e.V.. Erfurt, 04.-08.05.2005. Düsseldorf, Köln: German Medical Science; 2005. Doc05hno603

The electronic version of this article is the complete one and can be found online at:

Published: September 22, 2005

© 2005 Sauter et al.
This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( You are free: to Share – to copy, distribute and transmit the work, provided the original author and source are credited.



The external auditory canal cholesteatoma (EACC) is a rare disease with hyperprolieration and destructive growth in the adjacent structures. Down-regulation of beta-catenin is a pivotal factor for loose tissue integrity and invasiveness.. Transforming growth factor beta 1 (TGF-beta1) was reported to decrease beta-catenin in mammary epithelium. We investigated the abrogation of TGF-beta1 and beta-catenin expression in EACC culture cells. Cultured EACC-specimens were incubated with 6 micromol TGF-beta1 antisense. After 48h, expression of beta-catenin was determined by means of immunohistochemistry. The cells showed an increased mural reactivity to beta-catenin, and intracellular reactivity was unchanged. The predominant membranous location after treatment with TGF-beta1 antisense suggests increased tendency of the cells for tissue formation and strong cell-cell adhesion rather than migratory and invasive character, and thus TGF-beta1 antisense application is a useful therapeutical strategy.