gms | German Medical Science

MAINZ//2011: 56. GMDS-Jahrestagung und 6. DGEpi-Jahrestagung

Deutsche Gesellschaft für Medizinische Informatik, Biometrie und Epidemiologie e. V.
Deutsche Gesellschaft für Epidemiologie e. V.

26. - 29.09.2011 in Mainz

Colorectal cancer incidence and mortality among participants of colonoscopy screening

Meeting Abstract

  • Michael Hoffmeister - Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Heidelberg
  • Ulrike Haug - Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Im Neuenheimer Feld 581, 69120 Heidelberg, Division of Preventive Oncology, National Center for Tumor Diseases (NCT), Heidelberg
  • Christa Stegmaier - Saarland Cancer Registry, Saarbrücken
  • Hermann Brenner - Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Heidelberg

Mainz//2011. 56. Jahrestagung der Deutschen Gesellschaft für Medizinische Informatik, Biometrie und Epidemiologie (gmds), 6. Jahrestagung der Deutschen Gesellschaft für Epidemiologie (DGEpi). Mainz, 26.-29.09.2011. Düsseldorf: German Medical Science GMS Publishing House; 2011. Doc11gmds613

DOI: 10.3205/11gmds613, URN: urn:nbn:de:0183-11gmds6130

Published: September 20, 2011

© 2011 Hoffmeister et al.
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by-nc-nd/3.0/deed.en). You are free: to Share – to copy, distribute and transmit the work, provided the original author and source are credited.


Outline

Text

Background: Despite the lack of results from randomized trials, colonoscopy screening was introduced in Germany in late 2002. Concomitantly with the introduction of screening colonoscopy, a national registry of standardized screening colonoscopy records has been set up in Germany. This registry allows for cross-sectional analyses of screening adherence, of findings at colonoscopy, and of potential complications by age, sex, calendar year and region. However, records have to be kept anonymously, which prohibits longitudinal evaluation of reduction of colorectal cancer (CRC) incidence and mortality. In order to provide a longitudinal evaluation of the effectiveness of colonoscopy screening in Germany, the cohort study “KolosSal" was initiated state-wide in Saarland in 2005. Following recruitment of about 10,500 colonoscopy screening participants, this project includes registry-based follow-up of CRC incidence and mortality at the Saarland Cancer Registry.

Aims: CRC incidence and mortality rates among the cohort will be compared with those among the general population and with those among non-participants of colonoscopy screening. Furthermore, the frequency of interval cancers will be investigated and risk-adapted offers of colonoscopy screening will be evaluated among screening participants.

Methods: Since July 2005, participants of screening colonoscopy are recruited into the KolosSal study by 25 (almost all) gastroenterology practices in Saarland. Patients aged 55 or older with first residence in Saarland are asked to complete a standardized questionnaire on known and suspected risk factors for CRC (such as family history, smoking etc.). Colonoscopy and histology records from screening colonoscopy were requested from the gastroenterologists, and follow-up with respect to CRC incidence and mortality is conducted in cooperation with the Saarland Cancer Registry.

Meeting presentation: At the meeting, we will present the current project and publication status and, if possible, first results on the occurrence of interval cancers and deaths within 3 years after the initial screening colonoscopy.