gms | German Medical Science


Figure 1: The PKPD model of the exposure-response analysis. The drug substance is administered orally. The absorption into and the elimination from the body is modelled with exponentially distributed times ( 1/ka and 1/ke ). Based on the concentration in the disposition system, the effect function E(conc) is defining the QT(c) effect. Both the concentrations and the QTc effect are measured with errors.