gms | German Medical Science

7th EFSMA – European Congress of Sports Medicine, 3rd Central European Congress of Physical Medicine and Rehabilitation, Annual Assembly of the German and the Austrian Society of Physical Medicine and Rehabilitation

Austrian Society of Physical Medicine and Rehabilitation

26.-29.10.2011, Salzburg, Austria

Short term effect of an aerobic exercise program in a patient with neuroacanthocytosis syndromes: A case report

Meeting Abstract

7th EFSMA – European Congress of Sports Medicine, 3rd Central European Congress of Physical Medicine and Rehabilitation. Salzburg, 26.-29.10.2011. Düsseldorf: German Medical Science GMS Publishing House; 2011. Doc11esm204

doi: 10.3205/11esm204, urn:nbn:de:0183-11esm2041

Published: October 24, 2011

© 2011 Clemente Polán et al.
This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( You are free: to Share – to copy, distribute and transmit the work, provided the original author and source are credited.



Objective: The term “neuroacanthocytosis” describes a heterogeneous group of molecularly-defined disorders which result in progressive neurodegeneration, predominantly of the basal ganglia and erythrocyte acanthocytosis, their pathogenesis is still unknown. The clinical presentation of neuroacanthocytosis syndromes typically involves chorea and dystonia, but a range of other movement disorders may be seen. The aim of the present study was to investigate the ambulatory functionality and the importance of physical activity in a subject with neuroacanthocytosis syndrome, and its relationship to static-dynamic balance and postural control.

Material/Methods: Prospective, longitudinal and descriptive study. A male patient with neuroacanthocytosis syndrome and degree of disability 50 in functional scale MYERS was studied (age 42 years; height 164 cm; weight 70.2 kg). The following tests were performed: Timed Up and Go (TUG); hand-grip strength; Berg Balance Scale (BBS); 10 Meter Agility Shuttle Test (MAST); and exercise tolerance the 6-Minute Walk. Also Borg Perceived Exertion and Fatigue Severity Scale (FSS) were used. The supervised intervention had duration of 6 weeks, with a frequency of 2 days per week with training session of 45 minutes in treadmill. Workouts were based on a 70% aerobic volume capacity of 40–50% heart rate reserve (HRR), and 30% static balance training.

Results: The results of this study suggest a significant improvement in 10MAST (1.250 seconds), TUG (1.800 seconds), exercise tolerance (56 meters in 6MWT), static strength (near to 10 % in the upper extremity) and static-dynamic balance (BBS 42-48). In relation to FSS a moderate decrease was observed after the physical activity period. However, there were not significant important changes final heart rate (HR) in 6MWT after program.

Conclusion: The results of this study suggest that an aerobic exercise program of 6 weeks have significant influence on improvement of static and dynamic balance, and on increasing muscular strength in a patient with Neuroacanthocytosis. Not appear have an important influence in exercise tolerance. Therefore this intervention can be recommended in the functional recovery of Neuroacanthocytosis patients.


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