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7th EFSMA – European Congress of Sports Medicine, 3rd Central European Congress of Physical Medicine and Rehabilitation, Annual Assembly of the German and the Austrian Society of Physical Medicine and Rehabilitation

Austrian Society of Physical Medicine and Rehabilitation

26.-29.10.2011, Salzburg, Austria

Bone metabolism markers in sportswomen with menstrual cycle disfynctions

Meeting Abstract

  • corresponding author presenting/speaker Nenad Ponorac - Faculty of Medicne, Banja Luka, Bosnia Hercegovina
  • author Dragan Radovanovic - Faculty of Sport, Nis, Yugoslavia
  • author Stanislav Palija - Institute for Physical Medicine and Rehabilitation "Dr Miroslav Zotovic", Banja Luka, Bosnia Hercegovina
  • author Nenad Radjevic - Ministry of Family, Youth and Sport, Banja Luka, Bosnia Hercegovina
  • author Dejan Travar - Ministry of Family, Youth and Sport, Banja Luka, Bosnia Hercegovina

7th EFSMA – European Congress of Sports Medicine, 3rd Central European Congress of Physical Medicine and Rehabilitation. Salzburg, 26.-29.10.2011. Düsseldorf: German Medical Science GMS Publishing House; 2011. Doc11esm185

doi: 10.3205/11esm185, urn:nbn:de:0183-11esm1852

Published: October 24, 2011

© 2011 Ponorac et al.
This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( You are free: to Share – to copy, distribute and transmit the work, provided the original author and source are credited.



Objective: It is a well known fact that sportswomen with irregular menstrual cycle are exposed to the risk of diminished bone mineral density and consequentially osteoporosis may appear [1], [2]. Monitoring of the levels of biochemical markers of bone metabolism enables the understanding of the dynamic changes during the bone remodeling process [3].

The objectives of the conducted research were to determine the prevalence of menstrual dysfunctions in a sportswomen sample and a control group, as well as to determine the levels of bone metabolism markers in groups of women with menstrual dysfunctions.

Material/Methods: The women (n=117) were separated in two groups, the experimental (S) (n=84) comprised of three subgroups of sportswomen (34 sportswomen for ball games, 27 for athletics and 23 for sport dances) and the control group (C) (n=34). To determine the menstrual profile and dysfunction of the menstrual cycle, we used a very detailed questionnaire. The level of the midle, fragment of osteocalcin (N-MID osteocalcin) as the marker of bone formation, was determined, as well as the β-CrossLaps (β-CTx–bone resorption marker) via the electroluminescent immunochemistry method in the Elecsys 1010 automated machine.

Results: The primary amenorrhea was found in 7 (8,33%) and oligomenarrhea in 11 (13,09%) sportswomen That was statistically much higher incidence (p<0,05), than in the control group (0/34). Values of bone metabolism markers showed a statistically significant difference in the level of bone resorption marker, β-CrossLaps, between the groups of amneorrheic and oligomenarrheic sportswomen in comparison to eumenorrheic women, both sportswomen as well as those in the control group. Accelerated resorption was accompanied with accelerated bone formation.

Conclusion: Menstrual dysfunctions were statistically more present in the sportswomen group than in the control group and were accompanied with accelerated bone metabolism from the point of view of the increase of bone metabolism markers level.


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