gms | German Medical Science

7th EFSMA – European Congress of Sports Medicine, 3rd Central European Congress of Physical Medicine and Rehabilitation, Annual Assembly of the German and the Austrian Society of Physical Medicine and Rehabilitation

Austrian Society of Physical Medicine and Rehabilitation

26.-29.10.2011, Salzburg, Austria

Interrelation between apolipoprotein e polymorphism with cognitive impairments in boxers with mild traumatic brain injuries

Meeting Abstract

  • corresponding author S. Novikova - The state organization “Institute of Genetic and Regenerative Medicine of the Ukrainian Academy of Medical Sciences”, Kiyv, Ukraine
  • author presenting/speaker Andriy Muravskiy - National Medical Academy of Post-Graduate Education named after P.L. Shupyk, Kyiv, Ukraine
  • author presenting/speaker Iurii Dekhtiarov - Ukranian Centre of Sport Medicine, Kyiv, Ukraine

7th EFSMA – European Congress of Sports Medicine, 3rd Central European Congress of Physical Medicine and Rehabilitation. Salzburg, 26.-29.10.2011. Düsseldorf: German Medical Science GMS Publishing House; 2011. Doc11esm145

doi: 10.3205/11esm145, urn:nbn:de:0183-11esm1457

Published: October 24, 2011

© 2011 Novikova et al.
This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( You are free: to Share – to copy, distribute and transmit the work, provided the original author and source are credited.



Objective: To study the presence of a genetic predisposition to cognitive disorders based on the study of polymorphism of apolipoprotein E in patients with repeated mild traumatic brain injury (TBI).

Material/Methods: We examined 86 amateur boxers high skill level from age 18 to 32 years, playing a boxing classes ranging between 5 to 14 years. During a sports career boxers underwent TBI in the form knockdown and knockouts in number from 1 to 10. The control group included 30 people aged 18 to 25 years who had not a history transferred TBI, associated diseases of the nervous and cardiovascular systems. Was conducted neuropsychological research and genetic testing to determine the ApoE genotype and ApoE alleles.

Results: These neuropsychological tests shows a reduction of cognitive functions (mild cognitive impairment) in boxers with repeated mild TBI. The lowest test scores observed in patients with ε4 allele, and this difference is statistically reliable. In the control group rates of cognitive functions is slightly different from the norm. For frequency in both groups dominated allele ε3, a group of boxers often met alleles ε2 and ε4 compared with control group. In both groups dominated genotype ε3ε3, among a group of boxers often compared with the control group met genotypes ε2ε3 and ε3ε4. If the control group had never met the patients with genotype ε4ε4, then the group of boxers with repeated mild TBI had been four such cases, and found the boxer with the genotype ε4ε4 in which it was lowest neuropsychological tests.

Conclusion: Proved communication ApoE, including alleles ε4, with the development of cognitive disorders in boxers after deferred mild TBI. Genetic testing (determination ApoEε4) allows to predict the possibility of developing complications from the side of the nervous system after transferred TBI.