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7th EFSMA – European Congress of Sports Medicine, 3rd Central European Congress of Physical Medicine and Rehabilitation, Annual Assembly of the German and the Austrian Society of Physical Medicine and Rehabilitation

Austrian Society of Physical Medicine and Rehabilitation

26.-29.10.2011, Salzburg, Austria

The comparison of two types exercise on innate immune

Meeting Abstract

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  • corresponding author presenting/speaker Farah Nameni - Department of Physical Education, Islamic Azad University Branch Varamin - Pishva, Iran

7th EFSMA – European Congress of Sports Medicine, 3rd Central European Congress of Physical Medicine and Rehabilitation. Salzburg, 26.-29.10.2011. Düsseldorf: German Medical Science GMS Publishing House; 2011. Doc11esm139

doi: 10.3205/11esm139, urn:nbn:de:0183-11esm1396

Published: October 24, 2011

© 2011 Nameni.
This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( You are free: to Share – to copy, distribute and transmit the work, provided the original author and source are credited.



Objective: Studied have demonstrated that exercise induced considerable physiology change in the innate immune system.The interaction between exercise stress and the immune system provide a unique opportunity to evaluate the role of underlying stress and immunophysiological mechanisms .The purpose of the study was to comparison of two types exercise on innate immune.

Material/Methods: Eighteen active female, healthy volunteers participated in the study .Subjects were assigned in one of two groups: aerobic exercise (n=10)(age :21.6 ±1.71years, height: 161.45 ± 2.71cm, weight: 57.25±6.99 kg. and VO2,max 34.18 ±¯¹.min¯¹) and, exhaustion exercise(n=8), (age: 24.25±4.30 years, height: 159.81±4.86 cm, weight: 54.69±3.82 kg.and maximal oxygen consumption VO2, max: 36.1±3.79¯¹.min¯¹). The experimental protocol was approved by the ethics committee and all subjects were informed of the risks and purposes of the study before their written consent was obtained. Blood samples (n=18) were drawn from the antecubital vein before and immediately after aerobic exercise and exhaustion exercise (Bruce protocol). For cytokines measurement 11 ml blood sample was drawn. Plasma was separated from the cells and analysis for IL6 , IL1 and TNFα. Statistical analyses, tables, graph, means ± M±ME, t test used for measurement TNFα, IL1 and IL6 response (α was set at 0/05).

Results: Means showed the mean plasma concentration of TNFα increased, IL1 decreased and IL6 no changed after exhaustive exercise and the concentration of TNFα and IL1 decreased and IL6 no changed after endurance exercise. T-test showed changes of TNFα after endurance exercise was but another changes were not significant.

Conclusion: The exhaustion exercise is not very intensive or prolonged so, subjects were active and carbohydrate intake was not controlled in the present study and subjects can be assumed to be well loaded. Therefore changes of TNF, IL1 and IL6 were not significantly. Recent studies show that several cytokines can be detected in plasma during and after strenuous exercise. Endurance physical activity might reduce endothelial cell secretion of al IL1 and TNFα, both induces of an acute phase inflammatory response. More sensitive of kits and specific assays may be due to the fact that cytokines is produced locally and is rapidly cleared from the circulation. Both cross sectional and longitudinal studies support an inverse relationship between inflammatory cytokines and physical activity levels in healthy individual. Studied reported increased plasma TNF 2h after completing a 2•5h run (2h 30 min) and 1h after a 5 km race, respectively, but other studies have failed to detect TNF after exercise. Endurance exercise induces an decrease in the pro-inflammatory cytokines TNF. In conclusion, regular exercise protects against diseases associated with chronic low-grade systemic inflammation.

Key words: IL6, IL1, TNF, exhaustion, endurance


Gleesen M. Immune function in sport and exercise. Elsevier. 2006.
Pedersen BK, Toft AD. Effects of exercise on lymphocyte and cytokines. Br J Sports Med Sports Med. 2000;34:246-51.
Pedersen BK, Goetz LH. Exercise and the immune system: Regulation, Integration and Adaptation. Physiol Rev. 2000;80:1055-87.
Woods JA. Physical activity exercise and immune function. Brain, Behavior, Immunity. 2005;19:369-70.