gms | German Medical Science

104th DOG Annual Meeting

21. - 24.09.2006, Berlin

Cyanoacrylate versus fibrin glue in corneal perforations

Meeting Abstract

  • I. T. Shandurkov - Eye Department, University Hospital "St. Anna", Sofia, Bulgaria
  • P. V. Vassileva - Eye Department, University Hospital "St. Anna", Sofia, Bulgaria
  • A. D. Gantcheva - Eye Department, University Hospital "St. Anna", Sofia, Bulgaria
  • T. G. Hergeldzhieva - Eye Department, University Hospital "St. Anna", Sofia, Bulgaria

Deutsche Ophthalmologische Gesellschaft e.V.. 104. Jahrestagung der Deutschen Ophthalmologischen Gesellschaft (DOG). Berlin, 21.-24.09.2006. Düsseldorf, Köln: German Medical Science; 2006. Doc06dogDO.09.09

The electronic version of this article is the complete one and can be found online at:

Published: September 18, 2006

© 2006 Shandurkov et al.
This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( You are free: to Share – to copy, distribute and transmit the work, provided the original author and source are credited.




To compare clinical results from application of cyanoacrylate versus fibrin glue for occlusion in cases with corneal perforations as a result of autoimmune disease or ocular herpes.


5 patients with corneal perforations up to 2 mm in diameter and positive Seidel’s sign were included in our study. One patient (corneal perforation associated with ankylosing spondilitis) was treated with autologous fibrin glue. In the other 4 patients (three with perforated herpetic ulcer and one with corneal ulcer associated with rheumatoid arthritis) we applied cyanoacrylate glue. Soft contact lens was placed on the cornea after glue consolidation.


Excellent restoration of anterior chamber was achieved almost immediately after glue application. Severe hypotony was overcome and normal ocular pressure was measured on the first postoperative day. In spite of combined immunosuppressive therapy after glue application in the patient with ankylosing spondilitis the aggressive autoimmune melting of the cornea continued. All patients treated with cyanoacrylate glue kept corneal integrity even after removal of the glue two months later. During follow up period visual results were evaluated and underlying eye diseases treated as appropriate.


Application of autologous fibrin glue can provide temporary corneal occlusion, but it did not prevent further corneal melting in our patient with autoimmune disease - ankylosing spondilitis. Cyanoacrilate glue applied for small corneal lesions gives good long term results, because of its ability to adhere and hold fast for two or more months, during the self-healing processes restore ocular surface integrity.