gms | German Medical Science

104th DOG Annual Meeting

21. - 24.09.2006, Berlin

Needling revision with subconjunctival 5-Fluorouracil in failing filtering blebs after trabeculectomy

Meeting Abstract

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  • Z. Mandic - University Department of Ophthalmology, University Hospital "Sestre milosrdnice"
  • M. Geber-Zoric - University Department of Ophthalmology, University Hospital "Sestre milosrdnice"
  • G. Bencic - University Department of Ophthalmology, University Hospital "Sestre milosrdnice"

Deutsche Ophthalmologische Gesellschaft e.V.. 104. Jahrestagung der Deutschen Ophthalmologischen Gesellschaft (DOG). Berlin, 21.-24.09.2006. Düsseldorf, Köln: German Medical Science; 2006. Doc06dogDO.06.08

The electronic version of this article is the complete one and can be found online at:

Published: September 18, 2006

© 2006 Mandic et al.
This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( You are free: to Share – to copy, distribute and transmit the work, provided the original author and source are credited.




To evaluate a surgical technique to revise a failed filtering bleb, after trabeculectomy using subconjunctival 5-FU.


We reviewed retrospectively 24 consecutive eyes with bleb revisions. All eyes had previously functioning filtering bleb with inadequately controlled intraocular pressures (IOP) prior to the revisions. The procedure was usually performed as a clinic procedure, using a 27 G needle to lyse subconjunctival fibrosis and episcleral scar tissue binding down and elevate the scleral flap. 5-Fluorouracil (0,1 ml: 50mg/ml) was infiltrated around the bleb. The main outcome measures were IOP, number of glaucoma medications, and complications.


The mean follow-up time was 10,5±7,3 months (range 6-15 months). Intraocular pressure (IOP) decreased from 26,4±4,6 mmHg (range 18-31 mmHg) to 16,3±4,8 mmHg (range 8-28 mmHg). Twelve eyes achieved success, defined as IOP same or less than 18 mmHg without medications. Eleven eyes achieved qualified success (IOP same or less than 18 mmHg with antiglaucoma medications), and three eyes were classified as failures. Complications developed in 4 eyes (corneal epithelial defect, subconjunctival haemorrhage, temporary conjunctival leak and bullous keratopathy).


These data suggest that bleb needling with 5-FU is a safe and effective method by which a significant number of failed filtration bleb can be rescued from failure.