Article
Immunohistological localisation of advanced glycation end products (AGEs) in human preretinal membranes
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Authors
Published: | September 22, 2004 |
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Outline
Text
Objective
Advanced glycation end products (AGEs) play a role in the development of diabetic retinopathy. This study aimed to investigate if the AGE carboxymethyllysine (CML) could be identified in human preretinal membranes and if there are any differences between diabetic and non-diabetic patients.
Methods
25 surgically removed preretinal membranes (mean age 56,3 years, 19 diabetic, 6 non-diabetic) were investigated by immunohistological methods with a CML antibody.
Results
In nearly all investigated membranes CML could be identified. Nevertheless, clear differences between diabetic and non-diabetic patients could be shown. In membranes of diabetic patients much more immunoreactivity for CML could be found.
Conclusions
AGEs and especially CML may play a role in proliferation of preretinal membranes. Especially in diabetic patients a high immunoreactivity could be detected.