gms | German Medical Science

102. Jahrestagung der DOG

Deutsche Ophthalmologische Gesellschaft e. V.

23. bis 26.09.2004, Berlin

Immunohistological localisation of advanced glycation end products (AGEs) in human preretinal membranes

Meeting Abstract

  • corresponding author S. Thomas - University Eye Hospital Jena
  • J. Dawczynski - University Eye Hospital Jena
  • E. Königsdörffer - University Eye Hospital Jena
  • R. Augsten - University Eye Hospital Jena
  • S. Bramke - University Hospital Dresden, Dep. Anatomy
  • M. Kasper - University Hospital Dresden, Dep. Anatomy
  • S. Franke - University Hospital Jena, Dep. Internal Medicine
  • G. Stein - University Hospital Jena, Dep. Internal Medicine
  • J. Strobel - University Eye Hospital Jena

Evidenzbasierte Medizin - Anspruch und Wirklichkeit. 102. Jahrestagung der Deutschen Ophthalmologischen Gesellschaft. Berlin, 23.-26.09.2004. Düsseldorf, Köln: German Medical Science; 2004. Doc04dogP 179

The electronic version of this article is the complete one and can be found online at:

Published: September 22, 2004

© 2004 Thomas et al.
This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( You are free: to Share – to copy, distribute and transmit the work, provided the original author and source are credited.




Advanced glycation end products (AGEs) play a role in the development of diabetic retinopathy. This study aimed to investigate if the AGE carboxymethyllysine (CML) could be identified in human preretinal membranes and if there are any differences between diabetic and non-diabetic patients.


25 surgically removed preretinal membranes (mean age 56,3 years, 19 diabetic, 6 non-diabetic) were investigated by immunohistological methods with a CML antibody.


In nearly all investigated membranes CML could be identified. Nevertheless, clear differences between diabetic and non-diabetic patients could be shown. In membranes of diabetic patients much more immunoreactivity for CML could be found.


AGEs and especially CML may play a role in proliferation of preretinal membranes. Especially in diabetic patients a high immunoreactivity could be detected.