gms | German Medical Science

102. Jahrestagung der DOG

Deutsche Ophthalmologische Gesellschaft e. V.

23. bis 26.09.2004, Berlin

Exudative age-related macular degeneration in fluorescein angiograms and polarimetry

Meeting Abstract

  • corresponding author A. Weber - Schepens Eye Research Institute, Harvard Med. School, Boston/USA; Augenklinik des Universitätsklinikum Aachen
  • A.E. Elsner - Schepens Eye Research Institute, Harvard Med. School, Boston/USA
  • M.C. Cheney - Schepens Eye Research Institute, Harvard Med. School, Boston/USA
  • M. Miura - Tokyo Med. Univ., Inashiki/J
  • P. Salvetti - Clinique a Pare, Centre Nord Vision, Lille/F
  • A. Remky - Augenklinik des Universitätsklinikum Aachen

Evidenzbasierte Medizin - Anspruch und Wirklichkeit. 102. Jahrestagung der Deutschen Ophthalmologischen Gesellschaft. Berlin, 23.-26.09.2004. Düsseldorf, Köln: German Medical Science; 2004. Doc04dogP 159

The electronic version of this article is the complete one and can be found online at:

Published: September 22, 2004

© 2004 Weber et al.
This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( You are free: to Share – to copy, distribute and transmit the work, provided the original author and source are credited.




To compare exudative lesions due to age-related macular degeneration (AMD) in fluorescein angiograms (FA) and novel types of polarimetry images.


Images from 18 eyes with exudative AMD were graded by three experienced, blinded graders for the detection and localization of lesions, such as choroidal neovascularization (CNV) and leakage. Images included 3 polarimetry images (depolarized, birefringence and average image) and an early and late phase FA. Lesion didn't exceed 15 deg of size and the chosen FA's were of good quality. The polarimetry images were computed from raw data obtained by the GDx (LDT).


Graders detected CNV most confidently in the early phase FA and graded it significantly different from the next best image type, the average image (p=0.0017). Leakage was most confidently detected in the average image. The next best image type, the FA, wasn't graded significantly different from the average image (p=0.071), nor from the depolarized image (p=0.599). The birefringence was least favored for detection of both lesion types. The total area of the circled regions was higher for fluid than for CNV in all images; in the FA fluid area was 4.8 times larger than the CNV area, in the average image 6.8 times and in the depolarized image 3.5.


Experienced clinicians are most likely to detect CNV in early phase FA, when this is of good quality, but for the detection of the fluid component a noninvasive method was more effective. When the entire lesion was considered (CNV and leakage), a combination of different polarimetry information might help to evaluate an exudative lesion with similar precision as in the FA, but without pupil dilation and dye injection.