gms | German Medical Science

102. Jahrestagung der DOG

Deutsche Ophthalmologische Gesellschaft e. V.

23. bis 26.09.2004, Berlin

Spontaneous regression of retinal angiomatous vascular changes in v.-Hippel-Lindau syndrome

Meeting Abstract

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  • corresponding author D. Schmidt - Universitäts-Augenklinik, Freiburg
  • H. P. H. Neumann - Medizinische Universitätsklinik, Freiburg

Evidenzbasierte Medizin - Anspruch und Wirklichkeit. 102. Jahrestagung der Deutschen Ophthalmologischen Gesellschaft. Berlin, 23.-26.09.2004. Düsseldorf, Köln: German Medical Science; 2004. Doc04dogP 142

The electronic version of this article is the complete one and can be found online at:

Published: September 22, 2004

© 2004 Schmidt et al.
This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( You are free: to Share – to copy, distribute and transmit the work, provided the original author and source are credited.




In the literature, no documentation of a spontaneous regression of angiomatous retinal lesions have been found in long-term follow-up observations. Several authors presumed a spontaneous change of big angiomas into fibrotic lesions.


A 28-year-old woman (W.) who suffered from v. Hippel-Lindau syndrome was first examined at the age of 16 years. A 15-year-old patient (N.) showed several tumors with v. Hippel-Lindau syndrome.


At the age of 16 years, patient W. revealed a vascular anomaly and a circumscribed retinal edema adjacent to the optic disk. An examination nine years later showed a complete regression of the retinal vascular changes. A 15-year-old patient showed multiple small anastomosing vessels in the upper part of the left papilla, like moss fibres. At the age of 18 years a regression of these changes was found.


A spontaneous regression, mainly of minor angiomatous retinal lesions is possible.