gms | German Medical Science

102. Jahrestagung der DOG

Deutsche Ophthalmologische Gesellschaft e. V.

23. bis 26.09.2004, Berlin

Article

Send article

Therapy of normal tension glaucoma: hemodynamic effects of antiglaucomatous eye drops

Meeting Abstract

Search Medline for

  • corresponding author E. T. Matthiessen - Universitätsklinik Hamburg-Eppendorf, Klinik und Poliklinik für Augenheilkunde
  • O. Zeitz - Universitätsklinik Hamburg-Eppendorf, Klinik und Poliklinik für Augenheilkunde
  • L. Wagenfeld - Universitätsklinik Hamburg-Eppendorf, Klinik und Poliklinik für Augenheilkunde
  • P. Galambos - Universitätsklinik Hamburg-Eppendorf, Klinik und Poliklinik für Augenheilkunde
  • J. Reuss - Universitätsklinik Hamburg-Eppendorf, Klinik und Poliklinik für Augenheilkunde
  • A. Wiermann - Universitätsklinik Hamburg-Eppendorf, Klinik und Poliklinik für Augenheilkunde
  • M. Klemm - Universitätsklinik Hamburg-Eppendorf, Klinik und Poliklinik für Augenheilkunde

Evidenzbasierte Medizin - Anspruch und Wirklichkeit. 102. Jahrestagung der Deutschen Ophthalmologischen Gesellschaft. Berlin, 23.-26.09.2004. Düsseldorf, Köln: German Medical Science; 2004. Doc04dogP 093

The electronic version of this article is the complete one and can be found online at: http://www.egms.de/en/meetings/dog2004/04dog584.shtml

Published: September 22, 2004

© 2004 Matthiessen et al.
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by-nc-nd/3.0/deed.en). You are free: to Share – to copy, distribute and transmit the work, provided the original author and source are credited.

Outline

Text

Objective

Diminished ocular perfusion is a co-factor in the pathogenesis of normal tension glaucoma (NTG). Thus focus is on hemodynamic effects of locally applied antiglaucomatous drugs. In the present study, these effects of four common glaucoma eye drops are investigated.

Methods

Ocular hemodynamics in 52 patients with NTG were measured by Color Doppler Imaging (CDI) and Langham-OBF (LOBF) shortly before and after a one-month treatment with dorzolamide (n=15) or brinzolamide (n=8) or with latanoprost (n=10) or bimatoprost (n=11). In the control group (n=8) local and systemic medication was not changed. CDI measurements were performed with a Siemens Elegra (transducer: 7.5L40 ~9 MHz). For LOBF-measurements a clinical standard set-up was used.

Results

All applied substances lowered IOP. Treatment with dorzolamide accelerated blood flow in the posterior ciliary arteries in systole and diastole. In the brinzolamide, latanoprost and bimatoprost groups blood flow velocities tended to increase, but not statistically significantly. The LOBF did not change in any therapy group. In the control group all parameters including the IOP and the LOBF remained stable.

Conclusions

Only dorzolamide changes ocular hemodynamics; brinzolamide which like dorzolamide inhibits the carbonic-anhydrase did not. This leads to the conclusion that the hemodynamic effect of dorzolamide cannot be attributed to the inhibition of the carbonic-anhydrase. The hope for an easy improvement of ocular perfusion by local application of drugs established in glaucoma treatment seems to be an illusion. The positive message of this study is that none of the tested eye drops had negative influences on ocular hemodynamics.