gms | German Medical Science

102. Jahrestagung der DOG

Deutsche Ophthalmologische Gesellschaft e. V.

23. bis 26.09.2004, Berlin

Value of animal models for evidence based medicine (EBM)

Meeting Abstract

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  • corresponding author M. Seeliger - Retinal Electrodiagnostics Research Group, Department II, University Eye Hospital, Tübingen

Evidenzbasierte Medizin - Anspruch und Wirklichkeit. 102. Jahrestagung der Deutschen Ophthalmologischen Gesellschaft. Berlin, 23.-26.09.2004. Düsseldorf, Köln: German Medical Science; 2004. Doc04dogSO.07.01

The electronic version of this article is the complete one and can be found online at:

Published: September 22, 2004

© 2004 Seeliger.
This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( You are free: to Share – to copy, distribute and transmit the work, provided the original author and source are credited.



A central concept of EBM is the integration of individual clinical expertise and the best external evidence available; the latter meaning clinically relevant, often basic, research. The aim is to re-evaluate accepted diagnostic tests and therapeutic regimes in order to replace them by ones which are more effective, efficient, selective, and safe.

In particular in, but not limited to rare diseases, data from animal models may be an alternative source of information, as there is usually insufficient evidence from clinical trials.

This presentation focuses on the value of animal models of hereditary retinal degenerations for providing direct or indirect evidence that may influence human diagnostic and therapeutic procedures.