gms | German Medical Science

102. Jahrestagung der DOG

Deutsche Ophthalmologische Gesellschaft e. V.

23. bis 26.09.2004, Berlin

Investigations for the treatment of presbyopia with femtosecond laser pulses

Meeting Abstract

  • corresponding author G. Gerten - Laserforum Köln e.V., Köln
  • T. Ripken - Laser Zentrum Hannover e.V., Hannover
  • U. Oberheide - Laserforum Köln e.V., Köln
  • A. Heisterkamp - Laser Zentrum Hannover e.V., Hannover
  • O. Kermani - Laserforum Köln e.V., Köln
  • H. Lubatschowski - Laser Zentrum Hannover e.V., Hannover

Evidenzbasierte Medizin - Anspruch und Wirklichkeit. 102. Jahrestagung der Deutschen Ophthalmologischen Gesellschaft. Berlin, 23.-26.09.2004. Düsseldorf, Köln: German Medical Science; 2004. Doc04dogSO.04.02

The electronic version of this article is the complete one and can be found online at:

Published: September 22, 2004

© 2004 Gerten et al.
This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( You are free: to Share – to copy, distribute and transmit the work, provided the original author and source are credited.




According to Helmholtz' theory of accommodation one of the mayor reasons for the development of presbyopia is the increasing sclerosis of the lens. One concept to delay the process of sclerosis or even regain the elasticity of the lens material is the treatment of the lens by femtosecond laser pulses.


Our aim was to evaluate the appropriate laser parameters for this treatment. We performed different cutting patterns in enucleated porcine lenses (ex vivo) and in rabbit lenses (in vivo). The laser pulses had a repetition rate of 5 kHz and a pulse duration of 120 fs. The pulse energies and spot separation of the laser pulses were varied to investigate the effect on the generated cut.


The effect of the generated cut was first of all classified by light scattering of the residual gas bubbles. The cuts with the smallest amount of light scattering could be generated with pulse energies of 680 nJ and a spot separation of 5 μm. With these parameters a smooth cutting was possible in porcine eyes. In the in vivo investigations no cataract generation was observable in the rabbit eyes.


Fs laser pulses seem to be capable for generation of cuts in crystalline lens material without harmful side effects as our preliminary in vivo studies showed. Further investigations on human presbyopic lenses (ex vivo) have to be performed to evaluate a possible change in accommodation.