gms | German Medical Science

102. Jahrestagung der DOG

Deutsche Ophthalmologische Gesellschaft e. V.

23. bis 26.09.2004, Berlin

5-year follow-up after treatment with gamma knife in uveal melanoma

Meeting Abstract

  • corresponding author P.I. Foerster - Universitäts-Augenklinik der LMU, Munich
  • U. Schaller - Gamma-knife Center, Munich
  • B. Wowra - Universitäts-Augenklinik der LMU, Munich
  • A.J. Mueller - Universitäts-Augenklinik der LMU, Munich
  • A. Kampik - Universitäts-Augenklinik der LMU, Munich

Evidenzbasierte Medizin - Anspruch und Wirklichkeit. 102. Jahrestagung der Deutschen Ophthalmologischen Gesellschaft. Berlin, 23.-26.09.2004. Düsseldorf, Köln: German Medical Science; 2004. Doc04dogFR.11.11

The electronic version of this article is the complete one and can be found online at:

Published: September 22, 2004

© 2004 Foerster et al.
This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( You are free: to Share – to copy, distribute and transmit the work, provided the original author and source are credited.




Uveal melanoma with a maximal apical tumor height over 6 mm, a maximal basal diameter over 19 mm or with a peripapillary location are not suitable for treatment with Ru-106 brachytherapy. In addition to enucleation a treatment with gamma-knife is accessable in Munich for these patients since 1997. This study describes the 1-, 3-, and 5- year follow-up results according to local tumor control, and secundary enucleation rate.


In total, 116 patients (60 female, 56 male) were examined. The mean age at date of diagnosis was 60.5 years. 27 patients (23%) fullfilled a 5 year follow-up, 67 paptients (58%) a 3 year follow-up and 116 Patient a 1 year follow-up.


Local tumor control was achieved in 114 of 116 patients (98%). Due to failure of local tumor control 2 eyes (2%) were removed. Another 7 eyes (6%) were enucleated because of secondary glaucoma, 6 within the first two years after radiation,only one eye after three years.


In conclusion radiation with gamma-knife can be performed in one sesssion in patients with uveal melanoma. It offers a high level of local tumor control. Secondary glaucoma leading to enucleation is seen only within the first three years after treatment.