gms | German Medical Science

102. Jahrestagung der DOG

Deutsche Ophthalmologische Gesellschaft e. V.

23. bis 26.09.2004, Berlin

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Photodynamic therapy in pathologic myopia: importance of patient age and baseline visual acuity

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  • corresponding author A. Papp - 1st Dept. of Ophthalmology Semmelweis University, Budapest
  • A. Seres - 1st Dept. of Ophthalmology Semmelweis University, Budapest
  • T. Pregun - 1st Dept. of Ophthalmology Semmelweis University, Budapest
  • A. Szabó - 1st Dept. of Ophthalmology Semmelweis University, Budapest
  • Á. Borbándi - 1st Dept. of Ophthalmology Semmelweis University, Budapest
  • N. Czumbel - 1st Dept. of Ophthalmology Semmelweis University, Budapest
  • I. Süveges - 1st Dept. of Ophthalmology Semmelweis University, Budapest

Evidenzbasierte Medizin - Anspruch und Wirklichkeit. 102. Jahrestagung der Deutschen Ophthalmologischen Gesellschaft. Berlin, 23.-26.09.2004. Düsseldorf, Köln: German Medical Science; 2004. Doc04dogFR.03.15

The electronic version of this article is the complete one and can be found online at: http://www.egms.de/en/meetings/dog2004/04dog191.shtml

Published: September 22, 2004

© 2004 Papp et al.
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by-nc-nd/3.0/deed.en). You are free: to Share – to copy, distribute and transmit the work, provided the original author and source are credited.

Outline

Text

Objective

To investigate the influence of patient age and baseline visual acuity on the one-year results of photodynamic therapy in pathologic myopia.

Methods

One year visual acuity outcomes of cases of pathologic myopia (PM) underwent photodynamic therapy with verteporfin (PDT) in a 4 years period were reviewed. In contrast to the VIP study inclusion criteria, patients with baseline visual acuity between 20/200 and 20/100 were also included. Main outcome variables were mean change of visual acuity at 12 months. A subgroup analysis for patient age younger or older than 45 years and baseline visual acuity higher or lower than 20/100 was also performed.

Results

Out of 468 patients underwent PDT in the 1st Department of Ophthalmology, Semmelweis University, Budapest between april 2000 and december 2003, 70 patients had choroideal neovascularisation due to PM. Fifty-nine of them met the inclusion criteria of this study. There was no significant change in visual acuity at 3 or 12 months (results similar to that of the VIP study). Baseline visual acuity was significantly better in the younger (20/63) than in the older age group (20/100), however, younger patients gained on average 1.2 lines while older patients lost 1.7 lines.

Conclusions

Our results confirm the outcomes of the VIP study. In clinical practice, photodynamic therapy might be also considered for myopic patients with visual acuity 20/200 to 20/100 (i.e. under the limit of the VIP study). Older patients have a worse prognosis then younger myopes: 12 month results of the myopic patients older than 45 years are similar to that of patients with age- related macula degeneration.