Article
Role of factor V Leiden, PAI-1 4G/5G and Glycoprotein Ia/IIa 807C>T gene polymorphisms in central retinal vein occlusion
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Published: | September 22, 2004 |
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Outline
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Objective
Central retinal vein occlusion (CRVO) is a common cause for a severe visual loss affecting primarily patients older than 50 years. The precise contribution of thrombophilic gene polymorphisms to the development of CRVO is yet to be determined. The purpose of the present study was therefore to investigate the possible role of three common thrombophilic gene polymorphisms- factor V Leiden, PAI-1 4G/5G and glycoprotein Ia/IIa 807C>T - in CRVO.
Methods
The present study was designed as a case-control study including 176 patients with CRVO and 150 control subjects. Genotypes were determined by polymerase chain reaction.
Results
Mean age of patients with CRVO was 67.0±14.5 years and 69.7±12.1 years in control subjects. Genotype distribution of the investigated polymorphisms did not significantly differ between patients and control subjects (Factor V Leiden: 9 vs. 12, p=0.41; PAI-1 4G/4G: 44 vs. 50, p=0.13; GpIa/IIa 807TT: 28 vs. 23, p=1.0). Furthermore, the prevalence of arterial hypertension and diabetes mellitus was not significantly different between both groups.
Conclusions
None of the investigated gene polymorphisms seems to play a major role in the pathogenesis of CRVO.